Results 81 to 90 of about 1,227,442 (389)
A model for the self-organization of vesicular flux and protein distributions in the Golgi apparatus [PDF]
, 2013 The generation of two non-identical membrane compartments via exchange of vesicles is considered to require two types of vesicles specified by distinct cytosolic coats that selectively recruit cargo and two membrane-bound SNARE pairs that specify fusion ...
Ispolatov, Iaroslav, Muesch, Anne
core +3 more sources
β-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusion.
Biochemistry, 2015 Alzheimer's disease (AD) and Parkinson's disease (PD) are caused by β-amyloid (Aβ) and α-synuclein (αS), respectively. Ample evidence suggests that these two pathogenic proteins are closely linked and have a synergistic effect on eliciting ...
Bong-Kyu Choi +5 more
semanticscholar +1 more source
Kinetic diversity in the fusion of exocytotic vesicles [PDF]
The EMBO Journal, 1997 The speed at which secretory vesicles fuse with the plasma membrane is a key parameter for neuronal and endocrine functions. We determined the precise time courses for fusion of small clear and large dense-core vesicles in PC12 and chromaffin cells by simultaneously measuring both plasma membrane areas and release of vesicular contents.
Toshiko Yamazawa +5 more
openaire +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Vesicle Shrinking and Enlargement Play Opposing Roles in the Release of Exocytotic Contents
Cell Reports, 2020 Summary: For decades, two fusion modes were thought to control hormone and transmitter release essential to life; one facilitates release via fusion pore dilation and flattening (full collapse), and the other limits release by closing a narrow fusion ...
Wonchul Shin +11 more
doaj
Aging differentially affects multiple aspects of vesicle fusion kinetics.
PLoS ONE, 2011 How fusion pore formation during exocytosis affects the subsequent release of vesicle contents remains incompletely understood. It is unclear if the amount released per vesicle is dependent upon the nature of the developing fusion pore and whether full ...
Mark P Zanin +3 more
doaj +1 more source
Exocytotic fusion pore under stress
Cell Stress, 2020 Exocytosis is a universal process of eukaryotic cells, consisting of fusion between the vesicle and the plasma membranes, leading to the formation of a fusion pore, a channel through which vesicle cargo exits into the extracellular space.
Helena Haque Chowdhury, Robert Zorec
doaj +1 more source
Room for Two: The Synaptophysin/Synaptobrevin Complex
Frontiers in Synaptic Neuroscience, 2021 Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication. Aberrant molecular responses to calcium signaling at
Dustin N. White, Michael H. B. Stowell
doaj +1 more source
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
, 2019 Regulated exocytosis of synaptic vesicles is substantially faster than of endocrine dense core vesicles despite similar molecular machineries. The reasons for this difference are unknown and could be due to different regulatory proteins, different ...
Castle, J. +10 more
core +1 more source
Novel inner monolayer fusion assays reveal differential monolayer mixing associated with cation-dependent membrane fusion [PDF]
, 2000 The ability to specifically monitor the behavior of the inner monolayer lipids of membranous vesicles during the membrane fusion process is useful technically and experimentally.
Ali, Shaukat +3 more
core +1 more source