Results 21 to 30 of about 491,743 (295)

Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences

Proteomes, 2020
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions ...
Joames K. Freitas Leal, Edwin Lasonder, Vikram Sharma, Jürgen Schiller, Giuseppina Fanelli, Sara Rinalducci, Roland Brock, Giel Bosman   +7 more
doaj   +1 more source

Extracellular vesicles

GENETICS
Abstract Extracellular vesicles (EVs) encompass a diverse array of membrane-bound organelles released outside cells in response to developmental and physiological cell needs. EVs play important roles in remodeling the shape and content of differentiating cells and can rescue damaged cells from toxic or dysfunctional content. EVs can send
Juan Wang, Maureen M Barr, Ann M Wehman
openaire   +4 more sources

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft

Frontiers in Synaptic Neuroscience, 2010
Glutamate is released from synaptic vesicles following formation of a fusion pore, connecting the vesicle interior with the synaptic cleft. Release is proposed to result from either full fusion of the vesicle with the terminal membrane or by ‘kiss-
Jon T Brown, Kate L Weatherall, Laura R Corria, Thomas E Chater, John Isaac, Neil V Marrion   +5 more
doaj   +1 more source

Raspberry vesicles

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002
We present a method to control the osmotic stress of giant unilamellar vesicles (GUV) and we report an original shrinkage mode of the vesicles: the volume reduction is accompanied by the formation of inverted daughter vesicles which gives the shrunk vesicles the appearance of raspberries.
Bernard, Anne-Laure, Guedeau-Boudeville, Marie-Alice, Jullien, Ludovic, di Meglio, Jean-Marc   +3 more
openaire   +2 more sources

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

Frontiers in Immunology
Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic ...
Bo Shi, Caolingzhi Tang, Stephanie F. Rutter, Omar Audi, Dilara C. Ozkocak, Alice M. Trenerry, Daniel S. Simpson, Scott A. Williams, Quan T. Le, Gemma F. Ryan, Ponsuge T. M. Cooray, James E. Vince, Jason M. Mackenzie, Mark D. Hulett, Thanh Kha Phan, Ivan K. H. Poon   +15 more
doaj   +1 more source

Mechanisms tagging senescent red blood cells for clearance in healthy humans

Frontiers in Physiology, 2013
This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as ...
Anna eBogdanova, Hans U. Lutz
doaj   +1 more source

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line[S]

Journal of Lipid Research, 2016
Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the mechanism of their synergistic cytotoxicity is unclear.
Maria Podbielska, Zdzisław M. Szulc, Ewa Kurowska, Edward L. Hogan, Jacek Bielawski, Alicja Bielawska, Narayan R. Bhat   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source