Results 41 to 50 of about 520,160 (311)

Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity [PDF]

, 2020
Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular VesiclesGlycyl-tRNA synthetase 1 (GARS1), a cytosolic enzyme secreted from macrophages, promotes apoptosis in cancer cells ...
Won Suk Yang, Sehyun Chae, Chihong Song, Kim, Byung Gyu, Yong Song Gho, Gho, Yong Song, Hyun, Jae Kyung, Goughnour, Peter C, Yang, Won Suk, Cho, Seongmin, Song, Chihong, Daehee Hwang, Jung, Hyun Suk, Park, Min Chul, Kim, Sunghoon, Jun, Sangmi, Chae, Sehyun, Lee, Ji-Hyun, Hwang, Daehee, Min Chul Park, Ji‐Hyun Lee, Goughnour, Peter C., Lee, Ji‐Hyun, Jae Kyung Hyun, Seongmin Cho, Hyun Suk Jung, Sunghoon Kim, Sangmi Jun, Kim, Sang Bum, Peter C. Goughnour, Sang Bum Kim, Byung Gyu Kim   +31 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Scientific Reports
Traditional investigations of viral infection mechanisms have predominantly relied on two-dimensional (2D) cell culture models, which lack the structural organization and physiological relevance of native tissues.
Yi-Wen Chen, Huan-Jung Chiang, Kuan-Ting Liu, Chun-Wei Kao, Shan-Ren Xie, Chao-Ming Su, Yu-Yin Shih   +6 more
doaj   +1 more source

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

Frontiers in Immunology
Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic ...
Bo Shi, Caolingzhi Tang, Stephanie F. Rutter, Omar Audi, Dilara C. Ozkocak, Alice M. Trenerry, Daniel S. Simpson, Scott A. Williams, Quan T. Le, Gemma F. Ryan, Ponsuge T. M. Cooray, James E. Vince, Jason M. Mackenzie, Mark D. Hulett, Thanh Kha Phan, Ivan K. H. Poon   +15 more
doaj   +1 more source

Mechanisms tagging senescent red blood cells for clearance in healthy humans

Frontiers in Physiology, 2013
This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as ...
Anna eBogdanova, Hans U. Lutz
doaj   +1 more source

Polymersomes for biomedical applications : surface functionalization of silicone-based polymer vesicles [PDF]

, 2011
Polymersomes prepared from amphiphilic block copolymers are of great interest for applications in diagnostic and therapeutic medicine. In drug delivery, for instance, cargo-carrying polymersomes that can target and attach to specific cell receptors will ...
Egli, Stefan
core   +1 more source

Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells

, 2022
Aim: Elevated brain deposits of amyloid beta (Aβ40) contribute to neuropathology and cognitive dysfunction in Alzheimer’s disease (AD). However, the role of the blood-brain barrier (BBB) as an interface for the transfer of Aβ40 from the periphery into ...
Kowalczyk, Jennifer M, Louis, Kelssey D Pierre, Daftari, Manav T, Dykxhoorn, Derek M, Daftari, Manav T., Colbert, Brett M., Toborek, Michal, Kowalczyk, Jennifer M., András, Ibolya E., Dykxhoorn, Derek M., Colbert, Brett M, Torices, Silvia, Pierre Louis, Kelssey D., Osborne, Olivia M, András, Ibolya E, Naranjo, Oandy, Osborne, Olivia M.   +16 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line[S]

Journal of Lipid Research, 2016
Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the mechanism of their synergistic cytotoxicity is unclear.
Maria Podbielska, Zdzisław M. Szulc, Ewa Kurowska, Edward L. Hogan, Jacek Bielawski, Alicja Bielawska, Narayan R. Bhat   +6 more
doaj   +1 more source

Effects of Monovalent and Divalent Cations on Ca2+ Fluxes Across Chromaffin Secretory Membrane Vesicles [PDF]

, 1983
: Bovine chromaffin secretory vesicle ghosts loaded with Na+ were found to take up Ca2+ when incubated in K+ media or in sucrose media containing micromolar concentrations of free Ca2+. Li+- or choline+loaded ghosts did not take up Ca2+.
Gratzl, Manfred, Krieger-Brauer, H.
core   +1 more source