Results 51 to 60 of about 520,160 (311)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson’s disease

Frontiers in Cellular Neuroscience
Parkinson’s disease is a pathology with a wide range of in vivo and in vitro models available. Among these, the SH-SY5Y neuroblastoma cell line is one of the most employed.
Angel Carvajal-Oliveros, Camila Román-Martínez, Enrique Reynaud, Eduardo Martínez-Martínez   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Adhesion of vesicles

Physical Review A, 1990
A simple model for the adhesion of vesicles to interfaces and membranes is introduced and theoretically studied. It is shown that adhering (or bound) vesicles can exhibit a large variety of different shapes. The notion of a contact angle governed by tension is found to be applicable only for a restricted subset of these shapes. Furthermore, the vesicle
Seifert, Udo, Lipowsky, Reinhard
openaire   +5 more sources

Polymer–vesicle association [PDF]

Advances in Colloid and Interface Science, 2009
Mixed polymer-surfactant systems have been intensively investigated in the last two decades, with the main focus on surfactant micelles as the surfactant aggregate in interaction. The main types of phase behavior, driving forces and structural/rheological effects at stake are now fairly well understood.
Antunes, Filipe E., Marques, Eduardo F., Miguel, Maria G., Lindman, Björn   +3 more
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Shape transitions in anisotropic multicomponent lipid tubules

Frontiers in Materials, 2016
Ternary mixtures of saturated and unsaturated lipids together with cholesterol can be induced to phase separate by photo-peroxidation into lipid-ordered Lo and lipid-disordered Ld domains.
Tim eAtherton
doaj   +1 more source

Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy

, 2021
Bacterial outer membrane vesicles (OMV) have gained attention as a promising new cancer vaccine platform for efficiently provoking immune responses. However, OMV induce severe toxicity by activating the innate immune system.
Lötvall, Jan,, Svennerholm, Kristina,, Jan Lötvall, Crescitelli, Rossella,, Lässer, Cecilia,, Inta Gribonika, Rossella Crescitelli, Kristina Svennerholm, Kyong‐Su Park, Park, Kyong-Su,, Gribonika, Inta,, Cecilia Lässer   +11 more
core   +1 more source

Electron Cryomicroscopy of Bacteriorhodopsin Vesicles: Mechanism of Vesicle Formation [PDF]

Biophysical Journal, 1998
We obtained vesicles from purple membrane of Halobacterium halobium at different suspension compositions (pH, electrolytes, buffers), following the procedure of Kouyama et al. (1994) (J. Mol. Biol. 236:990-994). The vesicles contained bacteriorhodopsin (bR) and halolipid, and spontaneously formed during incubation of purple membrane suspension in the ...
Denkov, N., Yoshimura, H., Kouyama, T., Walz, J., Nagayama, K.   +4 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source