Results 51 to 60 of about 432,190 (268)
Journal of General Physiology, 2017 Slow fusion pore expansion could retain molecules within vesicles, enabling a chemical reaction that modifies secreted products.
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Cardiovascular DiabetologyBackground Gestational diabetes mellitus (GDM) affects 2–20% of pregnant women worldwide and is linked to fetal overgrowth, increased perinatal morbidity, and mortality, as well as a higher risk of developing cardiovascular disease later in life for ...
Nanthini Jayabalan +12 more
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Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
Proteomes, 2019 Previous systems-based proteomic approaches have characterized alterations in protein co-expression networks of unfractionated asymptomatic (AsymAD) and symptomatic Alzheimer’s disease (AD) brains. However, it remains unclear how sample fractionation and
Lenora Higginbotham +7 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
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DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
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Electron Cryomicroscopy of Bacteriorhodopsin Vesicles: Mechanism of Vesicle Formation [PDF]
Biophysical Journal, 1998 We obtained vesicles from purple membrane of Halobacterium halobium at different suspension compositions (pH, electrolytes, buffers), following the procedure of Kouyama et al. (1994) (J. Mol. Biol. 236:990-994). The vesicles contained bacteriorhodopsin (bR) and halolipid, and spontaneously formed during incubation of purple membrane suspension in the ...
Denkov, N. +4 more
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Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
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Physical Review A, 1990 A simple model for the adhesion of vesicles to interfaces and membranes is introduced and theoretically studied. It is shown that adhering (or bound) vesicles can exhibit a large variety of different shapes. The notion of a contact angle governed by tension is found to be applicable only for a restricted subset of these shapes. Furthermore, the vesicle
Seifert, Udo, Lipowsky, Reinhard
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Transient neonatal pustular melanosis: A possible cause of antibiotic misuse in neonates
Nigerian Journal of Medicine, 2020 The presence of pustules or vesiculo-pustular lesions in newborns is always a cause of concern both to the family and the attending physician. Transient neonatal pustular melanosis (TNPM) is a benign idiopathic skin condition characterized by vesicles ...
Dorathy Chinwe Obu +4 more
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