Results 71 to 80 of about 520,160 (311)

Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Cardiovascular Diabetology
Background Gestational diabetes mellitus (GDM) affects 2–20% of pregnant women worldwide and is linked to fetal overgrowth, increased perinatal morbidity, and mortality, as well as a higher risk of developing cardiovascular disease later in life for ...
Nanthini Jayabalan, Soumyalekshmi Nair, Andrew Lai, Katherin Scholz-Romero, Melissa Razo-Azamar, Valeska Ormazabal, Ratana Lim, Flavio Carrion, Dominic Guanzon, Gregory E. Rice, Harold David McIntyre, Martha Lappas, Carlos Salomon   +12 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

3D-printed magnesium/strontium-co-doped calcium silicate scaffolds promote angiogenesis and bone regeneration through synergistic bioactive ion stimulation

Journal of Biological Engineering
Bone defects resulting from trauma, infection, or surgical resection require biomaterials that support osteogenesis and vascularization for effective regeneration.
Chia-Che Ho, Tuan-Ti Hsu, Yung-Cheng Chiu, Yen-Hong Lin, Pei-Cheng Xie, Chen-Ying Wang   +5 more
doaj   +1 more source

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Dufès, Christine, Uchegbu, I.F., Couet, W., Tetley, L., Gray, A.I., Watson, D.G., Olivier, J.C., Schätzlein, A.G.   +7 more
core   +1 more source

Raspberry vesicles

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002
We present a method to control the osmotic stress of giant unilamellar vesicles (GUV) and we report an original shrinkage mode of the vesicles: the volume reduction is accompanied by the formation of inverted daughter vesicles which gives the shrunk vesicles the appearance of raspberries.
Bernard, Anne-Laure, Guedeau-Boudeville, Marie-Alice, Jullien, Ludovic, di Meglio, Jean-Marc   +3 more
openaire   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease

Proteomes, 2019
Previous systems-based proteomic approaches have characterized alterations in protein co-expression networks of unfractionated asymptomatic (AsymAD) and symptomatic Alzheimer’s disease (AD) brains. However, it remains unclear how sample fractionation and
Lenora Higginbotham, Eric B. Dammer, Duc M. Duong, Erica Modeste, Thomas J. Montine, James J. Lah, Allan I. Levey, Nicholas T. Seyfried   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication [PDF]

, 2017
In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes.
Puccia, R., Hansen, E.P., Bergese, P., Marcilla, A., Pereira-Chioccola, V., Nejsum, P., Øvstebø, R., Witwer, K., de la Canal, L., Soares, R.P., Schenkman, S., Colli, W., da Silva, L.L.P., Pfaffl, M.W., Criado, M.F., Del Portillo, H., Stensballe, A., Menezes-Neto, A., Olivier, M., Torrecilhas, A.C., Xander, P., Alves, M.J.M., Jaular, L.M., Nolte-T Hoen, E., Fritz, J., Ferreira, K.S., Gho, Y.S., Abdel Baqui, M.M., Riesbeck, K., Wauben, M., Costa, A.O.   +30 more
core   +2 more sources

Vesicles in Poiseuille Flow [PDF]

Physical Review Letters, 2009
Vesicle dynamics in unbounded Poiseuille flow is analyzed using a small-deformation theory. Our analytical results quantitatively describe vesicle migration and provide new physical insights. At low ratio between the inner and outer viscosity $λ$ (i.e.
Danker, Gerrit, Vlahovska, Petia, Misbah, Chaouqi   +2 more
openaire   +3 more sources