Results 31 to 40 of about 2,194 (135)

Altered Vesicular Acetylcholine Transporter Expression Regulates Acetylcholine Abundance in the Brain of Drosophila melanogaster

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
The vesicular acetylcholine transporter (VAChT) packages and transports the neurotransmitter acetylcholine (ACh) into synaptic vesicles for exocytosis, and its activity is necessary for essential life functions such as locomotion and cognition. Yet, the mechanism through which this important protein mediates ACh release is not fully understood. Here we
Rohina A. Nemat, Timothy Chaya, Angeline‐Claudia Atheby, Hakeem O. Lawal   +3 more
wiley   +1 more source

Neuropeptides: The Evergreen Jack‐of‐All‐Trades in Neuronal Circuit Development and Regulation

BioEssays, Volume 47, Issue 3, March 2025.
Neuropeptides provide an efficient alternative to fast neurotransmitters for synapses neurotransmission. Here, a perspective on the roles, eventual redundancy, and receptor‐level signal diversity of neuropeptides during neurodevelopment is provided through galanin as an example. Image shows thalamic neurons in Gal‐Cre:Ai9 mice. Courtesy of J.
Zsofia Hevesi, Tomas Hökfelt, Tibor Harkany   +2 more
wiley   +1 more source

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans [PDF]

, 2017
Starvationcauses comprehensivemetabolicchanges, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wildtype Caenorhabditis elegans and animals lacking the ...
Angelo, Azimifar, Barcia, Bjellqvist, Bjellqvist, Blumenthal, Brenner, Brosch, Cuervo, DePina, Depuydt, Dhondt, Dobin, Dong, Elle, Fredens, Grove, Grun, Hansen, Heestand, Heinz, Hojrup, Huang da, Huang da, Kang, Kent, Kent, Kim, Kimble, Lapierre, Larance, Larance, Larance, Leon, Liang, Liu, Ly, Ma, Magini, Maier, Murphy, Murtagh, Narayan, Narbonne, O'Rourke, Palgunow, Pang, Pena-Llopis, Robinson, Roczniak-Ferguson, Schaftenaar, Schwammle, Seah, Settembre, Settembre, Silva, Simonsen, Spivak, Tetlak, Van Rompay, Visscher, Visvikis, Vogel, Walther, Wang, Wilkins, Yang, Zimmerman   +67 more
core   +3 more sources

Targeting Polyamine Metabolism for Control of Human Viral Diseases [PDF]

, 2020
A virus is an infectious particle which generally contains nucleic acid genome (DNA or RNA inside a protein shell), except for human immunodeficiency virus (HIV). Viruses have to reproduce by infecting their host cells.
Chen, H, Huang, M, Zeng, J, Zhang, W
core   +1 more source

Memantine‐induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats

British Journal of Pharmacology, Volume 182, Issue 6, Page 1377-1393, March 2025.
Abstract Background and Purpose Slow‐acting biogenic amines, such as dopamine, are known to modulate fast neurotransmitters e.g. glutamate. In the striatum, dopamine (DA) interacts with glutamate, influencing neural excitability and promoting synaptic plasticity. The exact mechanism of such interaction is not fully understood.
Lucia Caffino, Giorgia Targa, Francesca Mottarlini, Sarah Thielens, Beatrice Rizzi, Agnes Villers, Laurence Ris, Raul R. Gainetdinov, Damiana Leo, Fabio Fumagalli   +9 more
wiley   +1 more source

Point‐of‐Care Health Diagnostics and Food Quality Monitoring by Molecularly Imprinted Polymers‐Based Histamine Sensors

Advanced Sensor Research, Volume 4, Issue 2, February 2025.
This review highlights recent advancements in molecularly imprinted polymers (MIPs) for electrochemical histamine sensing. It covers the selectivity, scalability, and efficiency of MIP sensors in food safety and healthcare. Key topics include histamine metabolism, MIP sensor synthesis and performance, and the integration of these technologies with AI ...
Shahzad Ahmed, Arshiya Ansari, Zhixuan Li, Hirak Mazumdar, Moin Ali Siddiqui, Afzal Khan, Pranay Ranjan, Ajeet Kaushik, Ajayan Vinu, Prashant Kumar   +9 more
wiley   +1 more source

Calcium homeostasis in the central nervous system: adaptation to neurodegeneration [PDF]

, 2001
En aquest article, després d'una revisió dels nostres coneixements bàsics sobre moviments del alci neuronal, s'ha resentat el treball fet pel nostre grup durant els últims anys sobre neurodegeneració, juntament amb les dades obtingudes en models animals ...
Adroer Martori, Rosa, Mahy, Nicole, Ramonet, David, Rodríguez, Manuel J., Yebra, Lluïsa de   +4 more
core  

The protein quality control system in motoneuron diseases [PDF]

, 2015
Spinal and bulbar muscular atrophy (SBMA) is a motoneuronal diseases caused by an elogated polyglutamine (polyQ) tract in the androgen receptor (AR).
Angelo Poletti, Elio Messi, Marco Meroni, Margherita Piccolella, Maria Elena Cicardi, Paola Rusmini, Riccardo Cristofani, Rita Galbiati, Valeria Crippa   +8 more
core   +1 more source

The Future of Nanomaterials Tackling the Challenge of Delivering Nucleic Acids to the Retina

Advanced Functional Materials, Volume 35, Issue 3, January 15, 2025.
Gene therapy is often the only hope for a cure for many retinal diseases. However, due to the unique anatomy of the eye, the introduction of such genes or nucleic acids is extremely challenging. This article presents various diseases, barriers, and challenges as well as methods and different nanomaterials that are used to deliver nucleic acids into the
José Hurst, Friederike Adams, Sven Schnichels   +2 more
wiley   +1 more source

Aqueous and Ethanol Extracts of Acacia sieberiana (Fabaceae) Stem Bark Reverse the Pain–Depression Dyad in Mice Through Modulation of Catecholamines, Proinflammatory Cytokines, and Oxidative Stress

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Rationale and Objective: The pain–depression dyad is highly prevalent and has reciprocal psychological and behavioral effects, leading to poor quality of life, increased disability, and challenging therapeutic outcomes. In an attempt to find better substances that can target pain–depression comorbidity, we examined the effect of aqueous (AE) and ...
Sorelle Ngassam Mbankou, Aliance Romain Fokoua, Cedric Wamba Koho, Roger Hermann Sadie Foguieng, Sahar Mofidi Tabatabaei, Pamela Arielle Nono Nankam, Kevin Joseph Tidgewell, Télesphore Benoît Nguelefack, Jirapornchai Suksaeree   +8 more
wiley   +1 more source