Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders [PDF]
, 2013 Prova tipográfica (uncorrected proof)Neurodevelopmental disorders such as epilepsy, intellectual disability (ID), and autism spectrum disorders (ASDs) occur in over 2 % of the population, as the result of genetic mutations, environmental factors, or ...
A Briancon-Marjollet +282 more
core +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]
, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
core +1 more source
Adrenaline and Noradrenaline: Partners and Actors in the Same Play" [PDF]
, 2012 info:eu-repo/semantics ...
Fernando Remião +5 more
core +2 more sources
Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy [PDF]
, 2020 Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter homeostasis. As such, they are implicated in a plethora of complex behaviors, including reward, movement, and cognition.
Gradisch, Ralph +4 more
core +1 more source
Effects of in vivo 3-iodothyronamine administration on gene expression in adipose tissue. [PDF]
, 2012 Thyroid hormones (THs) control the adipose tissue development and metabolism. They regulate both adipocyte proliferation and differentiation and, as they cause weight loss by increasing the metabolic rate, may be useful for obesity treatment.
MARIOTTI, VERONICA
core
Emerging Biomimetic Drug Delivery Nanoparticles Inspired by Extracellular Vesicles
WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 4, July/August 2025.An overview of various nanoparticles reviewed in this article and their mechanism of cellular targeting. ABSTRACT Nanoparticles (NPs) made up of cellular components such as extracellular vesicles (EVs) with a biomimetic outlook have emerged as a revolutionary approach in nanomedicine, providing significant benefits for targeted drug administration ...
Viswanathan Sundaram, Santosh Aryal
wiley +1 more source
Inhibition of DAT function attenuates manganese accumulation in the globus pallidus [PDF]
, 2007 Manganese (Mn) is an essential nutrient, though exposure to high concentrations may result in neurotoxicity characterized by alterations in dopamine neurobiology.
Erikson, Keith M. +1 more
core +1 more source
Methanobactin and the Link Between Copper and Bacterial Methane Oxidation [PDF]
, 2016 Methanobactins (mbs) are low-molecular-mass (
Bowman JP +37 more
core +1 more source