Results 11 to 20 of about 2,194 (135)
Vitamin C Transport Deficiency Alters Striatal Dopamine Gene Expression and Metabolism in YAC128 Huntington Disease Mice. [PDF]
Genes Brain BehavABSTRACT Neurodegeneration in Huntington disease (HD) contributes to dopaminergic system dysfunction via the loss of striatal medium spiny neurons expressing dopamine receptors. Given the key role for ascorbic acid (vitamin C) in dopamine synthesis and neurotransmission, we investigated whether mild cellular ascorbate deficiency accelerates ...
Tienda AA, Harrison FE, Wilcox JM.
europepmc +2 more sources
Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells. [PDF]
, 1994 Neurons and endocrine cells have two types of secretory vesicle that undergo regulated exocytosis. Large dense core vesicles (LDCVs) store neural peptides whereas small clear synaptic vesicles store classical neurotransmitters such as acetylcholine ...
Edwards, RH +5 more
core
ELECTROPHORESIS, EarlyView.This review provides a comprehensive summary of monoamine neurotransmitter analysis by capillary electrophoresis with amperometric detection. Fundamental principles of amperometric detection, electrode positioning strategies, and approaches to high‐voltage decoupling are described, followed by a critical comparison of electrode materials, selection of ...
Petr Kubáň +3 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 13, March 24, 2025.We have encapsulated a host–guest reporter pair together with three enzymes within vesicles to monitor a two‐compartment cascade reaction which includes transmembrane transport of peptide substrates and their subsequent enzymatic conversion inside the vesicles. Our “protocell” system mimics a simplistic cellular uptake‐metabolism cycle.
Ruixue Jiang +7 more
wiley +2 more sources
Journal of Neurochemistry, Volume 170, Issue 4, April 2026.Dopaminergic neurons are particularly susceptible to ferroptosis. Pacemaking activity–driven calcium (Ca2+) influx increases metabolic demand and reactive oxygen species (ROS) production, promoting iron release from aconitase. Alpha‐synuclein (α‐syn) enhances iron uptake via transferrin receptor 1 (TfR1) and exhibits ferrireductase activity, converting
Carmem L. Sperlich +2 more
wiley +1 more source
Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs [PDF]
, 2014 Many important drugs approved to treat common human diseases were discovered by serendipity, without a firm understanding of their modes of action. As a result, the side effects and interactions of these medications are often unpredictable, and there is ...
Aamodt, Eric +3 more
core +2 more sources
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Advanced Science, Volume 13, Issue 12, 27 February 2026.Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source
Astrocyte Regulation of Spinal Circuit Function
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
wiley +1 more source
Vesicular Amine Transporter VMAT2 in the Rat Ileum: from Principal Mechanism to Clinical Applications [PDF]
, 2015 Besides the role of a classical neurotransmitter, histamine plays a key role in the immune/inflammatory processes in the gastrointestinal tract. Specific transport proteins pack the amine neurotransmitters into vesicles so that their release can be ...
Stoyanova, I.I.
core +1 more source
Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.ABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Mariya Sigatullina Bondarenko +41 more
wiley +1 more source