Results 1 to 10 of about 2,194 (135)

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression. [PDF]

, 2014
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression.
Biedermann, T, Chou, M-T, Djapri, C, Hadi, R, Huang, B, Jang, J, Krantz, DE, Lam, HA, Lawal, HO, Lawless, GM, Maidment, NT, Roberts, L, Shahi, V, Terrell, A   +13 more
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Analysis of Synaptic Proteins in the Cerebrospinal Fluid as a New Tool in the Study of Inborn Errors of Neurotransmission [PDF]

, 2011
In a few rare diseases, specialised studies in cerebrospinal fluid (CSF) are required to identify the underlying metabolic disorder. We aimed to explore the possibility of detecting key synaptic proteins in the CSF, in particular dopaminergic and ...
A García-Cazorla, A García-Cazorla, A García-Cazorla, A Ormazabal, A Rustom, A Zougman, Ana Pérez, Angels García-Cazorla, C Mei De, Carlos Ortez, D Biou, E Thouvenot, EA Bolan, EA Cartier, FA Witzmann, I Corradini, I Marín-Valencia, J Eriksen, JA Kauer, JC Heyden Van Der, KE Sorra, LA Egaña, M Serrano, MA Willemsen, MG Harrington, Rafael Artuch, SB Glickstein, Sofia T. Duarte, TC Südhof, TC Südhof, TJ Volz, TJ Volz   +31 more
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Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources

Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB [PDF]

, 2016
The aim of this study was to evaluate the played by oxidative stress in the apoptotic response in different brain areas of rats chronically treated with supra-physiological doses of nandrolone decanoate (ND).
Busardo', FRANCESCO PAOLO, Cantatore, Santina, Cerretani, Daniela, Fineschi, Vittorio, Frati, Paola, Moltoni, Laura, Neri, Margherita, Pomara, Cristoforo, Riezzo, Irene, Turillazzi, Emanuela   +9 more
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Identification of a mammalian vesicular polyamine transporter [PDF]

, 2014
Spermine and spermidine act as neuromodulators upon binding to the extracellular site(s) of various ionotropic receptors, such as N-methyl-d-aspartate receptors. To gain access to the receptors, polyamines synthesized in neurons and astrocytes are stored
Harada, Yuika, Haruna, Yuka, Hiasa, Miki, Miyaji, Takaaki, Moriyama, Sawako, Moriyama, Yoshinori, Omote, Hiroshi, Takeuchi, Tomoya, Yamamoto, Akitsugu   +8 more
core   +1 more source

Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells [PDF]

, 2017
Pharmacological assays carried out in transfected cells have been very useful for describing the mechanism of action of cathinone new psychoactive substances (NPS).
A Chamba, A Derungs, A Rickli, A Rickli, A Rickli, AJ Eshleman, AJ Eshleman, AJ Eshleman, AV Kalueff, B Bang-Andersen, B Cara Di, B Hilber, B O’Neill, BG Wilhelm, BJ Thompson, BL Murray, BT Burlingham, C Achat-Mendes, C Hysek, C Pifl, CD Verrico, CG Tate, CM Hysek, CM Hysek, CM Hysek, CM Hysek, CM Hysek, CT Bauer, D Groskreutz, D Marazziti, D Sulzer, D Viggiano, DE Nichols, DM Mueller, EA Ross, EL Barker, F Xu, FA Ran, FG Revel, G Rudnick, H Khoshbouei, HA Borek, HC Prasad, I Sora, J Talvenheimo, JJ Maguire, JO Marcusson, L Iversen, L Jing, L Simmler, LD Simmler, LD Simmler, LD Simmler, LK Henry, LL Howell, LR Watterson, LR Watterson, M Liechti, M Raiteri, M Tatsumi, M Torok, MA Mergy, ME Liechti, MH Baumann, MH Baumann, MS Mazei-Robison, MT Brown, OT Ukairo, P Scholze, PJ Nelson, R Rosenauer, R Torre de la, R Zhang, RA Johnson, RA Prosser, RB Rothman, RB Rothman, RB Rothman, RB Rothman, S Chaudhary, S Ramamoorthy, S Wee, SB Caine, SL Hill, T Steinkellner, Y Cheng, Y Schmid, Y Schmid   +87 more
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Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution [PDF]

, 2010
Metaiodobenzylguanidine (MIBG) is an enzymatically stable synthetic analog of norepinephrine that when radiolabled with diagnostic ((123)I) or therapeutic ((131)I) isotopes has been shown to concentrate highly in sympathetically innervated tissues such ...
Babich, John W, Barrett, John A, Boyd, Marie, Femia, Frank J, Hillier, Shawn M, Joyal, John L, Kronauge, James F, Mairs, Robert J, Maresca, Kevin P   +8 more
core   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Targeting Glutamate Uptake To Treat Alcohol Use Disorders [PDF]

, 2015
Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol's effects, increased consumption, loss of control over drinking and the development of physical dependence.
Bell, Richard L., Engleman, Eric A., Rao, P. S. S., Sari, Youssef   +3 more
core   +2 more sources