Results 121 to 130 of about 146,054 (301)

Lysosomal Delivery of Bioactive Proteins to Living Human Cells via Engineered Exosomes [PDF]

, 2018
Exosomes are naturally secreted nanovesicles derived from mammalian cells that are used for intercellular communication in vivo. As a result, they can potentially be used for intracellular delivery of therapeutics for disease treatment. We have developed
Levy, Daniel
core   +1 more source

Phylogeographic Characterizations of Recent (2015–2023) Senecavirus A Isolates from Canada

Viruses
Senecavirus A (SVA) continues to cause vesicular lesions in swine in Canada and many regions worldwide. Since the vesicular lesions caused by SVA are similar to those caused by foot and mouth disease virus, swine vesicular disease virus and vesicular ...
Kate Hole, Oksana Vernygora, Katherine Handel, Michelle Nebroski, Oliver Lung, Charles Nfon, Shawn Babiuk   +6 more
doaj   +1 more source

Full Genomic Sequencing of Vesicular Stomatitis Virus Isolates from the 2004–2006 US Outbreaks Reveals Associations of Viral Genetics to Environmental Variables

Proceedings, 2020
Vesicular stomatitis (VS) outbreaks in the western USA occur cyclically, approximately every 8–10 years. Phylogenetic evidence based on a 450 nt region of the P coding sequences suggests that the initial introduction was a single viral lineage closely ...
Rachel Palinski, Steven Pauszek, N. Dylan Burruss, Heather Savoy, Angela Pelzel-McCluskey, Jonathan Arzt, Debra P.C. Peters, Luis Rodriguez   +7 more
doaj   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail [PDF]

, 1986
Truncated variants of the gene encoding H-2Ld, an integral membrane protein encoded by the major histocompatibility complex, were constructed by in vitro mutagenesis to elucidate the function of charged amino acids found on the cytoplasmic side of the ...
Hood, Leroy E., Zuñiga, Martha C.
core  

Rhabdovirus-based vaccine platforms against henipaviruses. [PDF]

, 2014
UNLABELLED: The emerging zoonotic pathogens Hendra virus (HeV) and Nipah virus (NiV) are in the genus Henipavirus in the family Paramyxoviridae. HeV and NiV infections can be highly fatal to humans and livestock.
Feldmann, Heinz, Kurup, Drishya, Marzi, Andrea, Schnell, Matthias J, Wirblich, Christoph   +4 more
core   +2 more sources

Improvement of the Anticancer Efficacy of PD‐1/PD‐L1 Blockade: Advances in Molecular Mechanisms and Therapeutic Strategies

MedComm, Volume 6, Issue 8, August 2025.
Mechanisms of alleviating resistance to PD‐1/PD‐L1 blockade by IFN‐α and IFN‐β. In these mechanisms, the “yin‐yang balance” is disrupted, thus preventing T cells from attacking cancer cells. Restoring this balance may improve the efficacy of anti‐PD‐1/PD‐L1 therapy and reinvigorate T cells and other immune cells to target and destroy cancer cells ...
Peng Gao, Xiao Li, Zhenyu Duan, Yang Wang, Yinggang Li, Jing Wang, Kui Luo, Jie Chen   +7 more
wiley   +1 more source

Direct detection and characterization of foot-and-mouth disease virus in East Africa using a field-ready real-time PCR platform [PDF]

, 2017
Effective control and monitoring of foot-and-mouth disease (FMD) relies upon rapid and accurate disease confirmation. Currently, clinical samples are usually tested in reference laboratories using standardized assays recommended by The World Organisation
Armson, B., Chepkwony, E., Cleaveland, S., Fowler, V. L., Gizaw, D., Howson, E.L.A., Kandusi, S., Kasanga, C. J., King, D. P., Lembo, T., Lyons, N. A., Mioulet, V., Ndusilo, N., Nelson, W. M., Rauh, R., Wood, B. A., Yamazaki, W.   +16 more
core   +1 more source

High Cell Density Perfusion Process of Quail Cells Producing Oncolytic rVSV‐NDV

Engineering in Life Sciences, Volume 25, Issue 7, July 2025.
ABSTRACT Oncolytic viruses as agents for the treatment of various types of cancer have demonstrated their potential in many clinical studies over the past decades. In particular, rVSV‐NDV (a recombinant vesicular stomatitis virus [VSV] construct with fusogenic Newcastle disease virus glycoproteins) shows promising preclinical results.
Lennart Jacobtorweihe, Sven Göbel, Markus Wolschek, Jennifer Altomonte, Udo Reichl, Yvonne Genzel   +5 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source