Results 131 to 140 of about 2,100 (161)

Characterizing oncolytic potential and safety of a G-protein pseudotyped vesiculovirus in sarcoma

Journal of Immunology, 2022
Several vesicular stomatitis virus (VSV)-based oncolytic therapies have advanced to phase II clinical trials for treatment of solid tumors. As most antibodies produced after VSV infection are directed towards the surface glycoprotein (G), switching ...
C. Dumbauld, M. Seetharam, B. Nagalo, M. Borad   +3 more
semanticscholar   +1 more source

Immunoinformatics based designing a multi‐epitope vaccine against pathogenic Chandipura vesiculovirus

Journal of Cellular Biochemistry, 2021
Chandipura vesiculovirus (CHPV) is a rapidly emerging pathogen responsible for causing acute encephalitis. Due to its widespread occurrence in Asian and African countries, this has become a global threat, and there is an urgent need to design an ...
Debashrito Deb, Srijita Basak, Tamalika Kar, Utkarsh Narsaria, F. Castiglione, Abhirup Paul, A. Pandey, A. Srivastava   +7 more
semanticscholar   +1 more source

Chandipura Vesiculovirus: Clinical Manifestation, Neuroinvasion and Public Health Interventions

International Journal of Health Sciences and Research
Chandipura virus (CHPV), a vesiculovirus in the Rhabdoviridae family, has emerged as a critical pathogen responsible for severe encephalitis outbreaks in rural India, predominantly affecting children.
Harsahaj Singh Wilkhoo, Harkirat Singh Wilkhoo   +1 more
semanticscholar   +1 more source

Metabolomics captures the differential metabolites in the replication pathway of snakehead vesiculovirus regulated by glutamine.

Diseases of Aquatic Organisms
Snakehead vesiculovirus (SHVV) is a negative-sense single-stranded RNA virus that infects snakehead fish. This virus leads to illness and mortality, causing significant economic losses in the snakehead aquaculture industry.
Binbin Sun, Yulei Zhang, Keping Chen, Lindan Sun   +3 more
semanticscholar   +1 more source

Abstract 588: Preclinical evaluation of novel chimeric vesiculovirus mediated expression of proteolytic enzymes targeting two major stromal components of pancreatic ductal adenocarcinoma

Cancer Research
The vesiculovirus genus has recently garnered interest as an oncolytic virotherapy for pancreatic ductal adenocarcinoma (PDAC). A new synthetic chimeric vesiculovirus, VMG, demonstrated efficacy and safety against PDAC both in vitro and in vivo.
K. U. Ferdous, M. Tesfay, Camila C Simoes, Aleksandra Cios, B. Nagalo   +4 more
semanticscholar   +1 more source

Application and development of a TaqMan-based real-time PCR assay for rapid detection of snakehead vesiculovirus.

FEMS Microbiology Letters
Snakehead vesiculovirus (SHVV) is one of the primary pathogens responsible for viral diseases in the snakehead fish. A TaqMan-based real-time PCR assay was established for the rapid detection and quantification of SHVV in this study. Specific primers and
Cuiping Gong, Panpan Zhu, Jiaxin Ye, Jianfeng Lou, Liwen Zhang, Xiaodan Liu, Weiguang Kong   +6 more
semanticscholar   +1 more source

Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response

Cancer Research
Vesicular stomatitis virus (VSV) is one of the leading oncolytic virus prototypes used in both preclinical and clinical cancer research. A newly engineered chimeric vesiculovirus, VMG, has been tested against various cancer types, including pancreatic ...
K. U. Ferdous, M. Tesfay, Aleksandra Cios, I. Miousse, B. Nagalo   +4 more
semanticscholar   +1 more source

Broad geographical circulation of a novel vesiculovirus in bats in the Mediterranean region.

PLoS Neglected Tropical Diseases
Bats are the natural reservoirs for a variety of emerging and re-emerging viruses. Among them, rabies virus (genus Lyssavirus, family Rhabdoviridae) is one of the first and most emblematic described in these animals.
Dong-Sheng Luo, Markéta Harazim, Corinne Maufrais, Simon Bonas, N. Martínková, A. Lalis, Emmanuel Nakouné, E. V. Adjogoua, Mory Douno, B. Kadjo, M. López-Roig, Jiří Pikula, Zheng-Li Shi, H. Bourhy, J. Serra-Cobo, L. Dacheux   +15 more
semanticscholar   +1 more source

X‐Ray Crystallography Based Epitope Mapping of Glycoproteins and RNA in Chandipura Vesiculovirus for Vaccine Design

Immunology
This study investigates potential epitopes in the glycoprotein and RNA of Chandipura vesiculovirus (CHPV) using MHC Class I (HLA‐A0201) and MHC Class II (DRB1_0101) molecules with 3D structures derived from x‐ray crystallography.
Aron Rodrick Lakra
semanticscholar   +1 more source