Results 71 to 80 of about 263,648 (295)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Superficial Retinal Microvasculature and Choriocapillaris Alterations after Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Journal of Ophthalmology, 2022
Purpose. To compare superficial retinal vascular, choriocapillaris (CC), and choroidal thickness changes in chronic central serous chorioretinopathy (CSCR) patients after half-dose photodynamic therapy (PDT). Method.
Morteza Entezari, Iman Ansari, Alireza Ramezani, Humayoun Nikkhah, Parisa Mohammadi, Bahar Kheiri   +5 more
doaj   +1 more source

Optic nerve head grid used for vessel density measurement.

, 2023
Optic nerve head grid used for vessel density measurement.
Ingrida Januleviciene (5122124), Alon Harris (508127), Agne Markeviciute (16426018), Brent Siesky (9262135), Gal Antman (16426021)   +4 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography

Journal of Ophthalmology, 2019
Purpose. To evaluate the changes in retinal vessel density and thickness after small incision lenticule extraction (SMILE) with optical coherence tomography angiography (OCTA) in myopic patients. Methods.
Minjie Chen, Jinhui Dai, Lan Gong
doaj   +1 more source

Evaluation of Foveal Avascular Zone in Diabetic Hypertensive Patients Versus Diabetics Using Optical Coherence Tomography Angioghraphy [PDF]

Al-Azhar International Medical Journal
Background: Diabetic retinopathy (DR) is considered a major cause of vision loss. While fundus fluorescence angiography (FFA) has been widely used for diagnosis, it is invasive. Optical coherence tomography angiography (OCTA) is considered a non-invasive
Farrag Farrag, Ali Khalifa, Hassan Bayoumy   +2 more
doaj   +1 more source

In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in mice. [PDF]

PLoS ONE, 2011
PURPOSE: Inhibition of angiogenesis has shown clinical success in patients with cancer. Thus, imaging approaches that allow for the identification of angiogenic tumors and the detection of response to anti-angiogenic treatment are of high clinical ...
Roland T Ullrich, Jan F Jikeli, Michael Diedenhofen, Philipp Böhm-Sturm, Maike Unruh, Stefan Vollmar, Mathias Hoehn   +6 more
doaj   +1 more source

Quantification of blood vessel density.

, 2014
Blood vessel (BV) density was first quantified in the contralateral (control) hemisphere in the cortex and striatum of Nox2 WT and Nox2 KO mice at 24 h and 72 h post-stroke (A).
Gregory J. Dusting (406741), Sarah K. McCann (655666), Carli L. Roulston (561410)   +2 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source