Results 81 to 90 of about 5,151,337 (299)

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Educational Impact of a 3D Canine Vascular Simulator for Learning Anatomy and Interventional Radiology Techniques in Veterinary Training

Veterinary Sciences
Background: Simulation-based teaching is increasingly important in veterinary training, especially for learning anatomy and interventional techniques where real-life exposure is limited.
Sandra Lopez-Minguez, Iris Urbano, Ignacio de Blas, Cantal del Rio-Martinez, Cristina Bonastre, Jose Andres Guirola, Jose Benito Rodriguez, Francisco Javier Miana-Mena, Carolina Serrano-Casorran   +8 more
doaj   +1 more source

ChatGPT in veterinary medicine: a practical guidance of generative artificial intelligence in clinics, education, and research [PDF]

Frontiers in Veterinary Science
ChatGPT, the most accessible generative artificial intelligence (AI) tool, offers considerable potential for veterinary medicine, yet a dedicated review of its specific applications is lacking.
Candice P. Chu
semanticscholar   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Utilization and acceptance of virtual patients in veterinary basic sciences – the vetVIP-project

GMS Journal for Medical Education, 2017
Context: In medical and veterinary medical education the use of problem-based and cased-based learning has steadily increased over time. At veterinary faculties, this development has mainly been evident in the clinical phase of the veterinary education ...
Kleinsorgen, Christin, Kankofer, Marta, Gradzki, Zbigniew, Mandoki, Mira, Bartha, Tibor, von Köckritz-Blickwede, Maren, Naim, Hassan Y., Beyerbach, Martin, Tipold, Andrea, Ehlers, Jan P.   +9 more
doaj   +1 more source

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula [PDF]

, 2021
Carmen Espinosa‐Gongora, Lisbeth Rem Jessen, Oliver J. Dyar, Alain Bousquet‐mélou, Bruno González‐Zorn, C. Pulcini, Re G, Štefan Schwarz, Dorina Timofte, Pierre‐Louis Toutain, Luca Guardabassi, The PREPARE-VET Working Group, ESCMID Study Group for Veterinary Microbiology (ESGVM), ESCMID Study Group for Antimicrobial stewardshiP (ESGAP)   +13 more
openalex   +1 more source