Results 31 to 40 of about 1,455 (196)

Vacuolization of hematopoietic precursors: an enigma with multiple etiologies [PDF]

, 2021
Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome.
Awada, Hassan, Carraway, Hetty E, Durkin, Lisa, Gurnari, Carmelo, Hsi, Eric D, Kongkiatkamon, Sunisa, Maciejewski, Jaroslaw P, Pagliuca, Simona, Rogers, Heesun J, Terkawi, Laila, Visconte, Valeria, Zawit, Misam   +11 more
core   +1 more source

VEXAS syndrome: a new paradigm for adult-onset monogenic autoinflammatory diseases [PDF]

, 2023
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a recently described pathological entity. It is an acquired monogenic autoinflammatory disease caused by somatic mutations of the UBA1 gene in blood cells precursors; the gene ...
Bimonte, Antonio, Bocchia, Monica, Caggiano, Valeria, Cantarini, Luca, Caroni, Federico, Fabbiani, Alessandra, Fabiani, Claudia, Frediani, Bruno, Renieri, Alessandra, Tosi, Gian Marco, Vitale, Antonio   +10 more
core   +1 more source

VEXAS syndrome in a nutshell [PDF]

, 2023
VEXAS is a multisystem autoinflammatory disorder caused by acquired somatic mutations in the ubiquitin-like modifier activating the X chromosome's enzyme 1 (UBA1) gene.
Harun, Nurul Hazliana
core   +3 more sources

Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome

Experimental Hematology & Oncology, 2022
VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is ...
Valentin Lacombe, Annaelle Beucher, Geoffrey Urbanski, Yannick Le Corre, Laurane Cottin, Anne Croué, Anne Bouvier   +6 more
doaj   +1 more source

Vasculitis associated with VEXAS syndrome: A literature review

Frontiers in Medicine, 2022
Vasculitis is an inflammatory disorder of the blood vessels that causes damage to a wide variety of organs through tissue ischemia. Vasculitis is classified according to the size (large, medium, or small) of the blood vessels.
Ryu Watanabe, Manami Kiji, Motomu Hashimoto   +2 more
doaj   +1 more source

Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With VEXAS Syndrome: An International Multicenter Study. [PDF]

Arthritis Rheumatol
Objective The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome. Methods This multicenter international study includes patients with VEXAS from France, Israel, and Italy treated with ...
Eviatar T, Capelusnik D, Campochiaro C, Lacombe V, Jachiet V, Zisapel M, Sagy I, Tayer-Shifman OE, Ozeri D, Kivity S, Tomelleri A, Terrier B, Peleg H, Comont T, Sacre K, Woaye-Hune P, Arnaud L, Lazaro E, Grobost V, Lifermann F, Samson M, Ardois S, Garnier A, Maria A, Cantagrel A, Meyer A, Bouaziz JD, Heiblig M, Dagna L, Diral E, Kosmider O, Elkayam O, Hadjadj J, Georgin-Lavialle S, Fain O, Mekinian A.   +35 more
europepmc   +2 more sources

[Treatment of VEXAS syndrome]. [PDF]

Z Rheumatol
Krusche M.
europepmc   +5 more sources

Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation [PDF]

, 2023
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in hematopoietic stem cells constitute the genetic basis of VEXAS.
Alexander T., Bruno A., Greco R., Gurnari C., Snowden J. A.   +4 more
core   +1 more source

Recurrent superior orbital fissure syndrome associated with VEXAS syndrome

Journal of Ophthalmic Inflammation and Infection, 2023
Purpose To describe a case of recurrent orbital inflammation and superior orbital fissure syndrome associated with VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome. Case presentation VEXAS syndrome is a recently identified multi-
Katie Myint, Namritha Patrao, Oana Vonica, Kaveh Vahdani   +3 more
doaj   +1 more source

Patients with VEXAS diagnosed in a Danish tertiary rheumatology setting have highly elevated inflammatory markers, macrocytic anaemia and negative autoimmune biomarkers [PDF]

, 2022
BACKGROUND: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is an autoinflammatory condition with overlapping features of rheumatology and haematology caused by somatic mutations in the UBA1 gene.
Hauge, Ellen-Margrethe, Jensen, Jens Magnus Bernth, Nielsen, Kirstine Overgaard, Rasch, Mads Nyhuus Bendix, Szabados, Fruzsina, Troldborg, Anne   +5 more
core   +3 more sources