Results 1 to 10 of about 59,366 (164)

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes [PDF]

Nature Communications, 2017
The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3).
Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin, Hiroaki Kiyokawa   +10 more
doaj   +2 more sources

Causal relationship between genetically predicted Enzyme and Tinnitus risk: a two-sample bi-directional mendelian randomization study [PDF]

Brazilian Journal of Otorhinolaryngology
Objectives: Observational studies have reported an association between enzymes and tinnitus. However, the exact nature and strength of the causal relationship between enzymes and tinnitus remain unclear.
Peng Liu, Xinmiao Xue, Zhixin Zhang, Lijun Zhang, Yu Peng, Qi Song, Fangyuan Wang   +6 more
doaj   +2 more sources

Molecular Functions of Ubiquitin-like Modifiers in Bacterial Infection [PDF]

Cells
Ubiquitin-like proteins (UBLs) such as SUMO, NEDD8, ISG15, FAT10, and UFM1 are proteins that share structural similarities to ubiquitin. Like ubiquitin, they function as protein modifiers, catalyzing modifications through a conserved enzymatic cascade of
Tohru Tezuka, Wei Jie Nicholas Yang, Keisuke Kitahata, Aya Nohara, Sun Joo Park, Minsoo Kim   +5 more
doaj   +2 more sources

Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme [PDF]

Structure, 2017
Targeting the activating enzymes (E1) of ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) has emerged as a promising anti-cancer strategy, possibly overcoming the ineffectiveness of proteasome inhibitors against solid tumors. Here, we report crystal structures of the yeast ubiquitin E1 (Uba1) with three adenosyl sulfamate inhibitors exhibiting ...
Alexander Statsyuk, Hermann Schindelin, Maximilian Springmann   +2 more
exaly   +3 more sources

The deubiquitinase USP35: from an oncogenic hub to a therapeutic target in human cancers [PDF]

Frontiers in Oncology
Ubiquitination is a critical post-translational modification in eukaryotic cells, mediated by a sequential enzymatic cascade involving E1 (activating), E2 (conjugating), and E3 (ligase) enzymes that catalyze the covalent conjugation of ubiquitin to ...
Bisheng Li, Yuhong Wen, Rubin Wang, Jianhua Xiao, Wenjie Liao, Yihao Liao, Honggang Yuan   +6 more
doaj   +2 more sources

MALDI-TOF Mass Spectrometry for interrogating ubiquitin enzymes

Frontiers in Molecular Biosciences, 2023
The attachment of ubiquitin to a substrate (ubiquitination or ubiquitylation) impacts its lifetime and regulates its function within the cell. Several classes of enzymes oversee the attachment of ubiquitin to the substrate: an E1 activating enzyme that ...
Virginia De Cesare
doaj   +1 more source

Decoding the ubiquitin-mediated pathway of arthropod disease vectors. [PDF]

PLoS ONE, 2013
Protein regulation by ubiquitin has been extensively described in model organisms. However, characterization of the ubiquitin machinery in disease vectors remains mostly unknown.
Anthony Choy, Maiara S Severo, Ruobai Sun, Thomas Girke, Joseph J Gillespie, Joao H F Pedra   +5 more
doaj   +1 more source

Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1

Antioxidants, 2023
Protein ubiquitination, which is catalyzed by ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, is a crucial post-translational modification to regulate numerous cellular functions in a spatio–temporal-specific manner ...
Daisuke Oikawa, Kouhei Shimizu, Fuminori Tokunaga   +2 more
doaj   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

Molecules, 2021
The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +1 more source

Evolution of the ubiquitin-activating enzyme Uba1 (E1) [PDF]

Physica A: Statistical Mechanics and its Applications, 2017
Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies ...
Allan, Douglas C., Phillips, J. C.
openaire   +2 more sources