Results 11 to 20 of about 59,465 (263)
Crystal Structure of a Fragment of Mouse Ubiquitin-activating Enzyme [PDF]
Journal of Biological Chemistry, 2005 Protein ubiquitination requires the sequential activity of three enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-ligase (E3). The ubiquitin-transfer machinery is hierarchically organized; for every ubiquitin-activating enzyme, there are several ubiquitin-conjugating enzymes, and most ubiquitin ...
Szczepanowski, R. +2 more
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Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants
Cells, 2020 All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in
Tong Su +4 more
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Targeting the ubiquitin system by fragment-based drug discovery
Frontiers in Molecular Biosciences, 2022 The ubiquitin system contains a wealth of potential drug targets for many diseases and conditions, including neurodegenerative, immune, metabolic and developmental diseases, as well as multiple cancers.
Cassandra Kennedy +2 more
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Homology Modelling of Human E1 Ubiquitin Activating Enzyme [PDF]
Letters in Drug Design & Discovery, 2010 Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
Brahemi, Ghali +3 more
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TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets
Frontiers in Chemistry, 2019 Protein modification by Ubiquitin or Ubiquitin-like modifiers is mediated by an enzyme cascade composed of E1, E2, and E3 enzymes. E1s, or ubiquitin-activating enzymes, perform ubiquitin activation. Next, ubiquitin is transferred to ubiquitin-conjugating
Daniel Salas-Lloret +2 more
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UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses
Frontiers in Endocrinology, 2023 The UFM1 conjugation system(UFMylation)is a novel type of ubiquitin-like system that plays an indispensable role in maintaining cell homeostasis under various cellular stress.
Qiang Jiang +9 more
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Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation [PDF]
Cells, 2021 Ubiquitination is a crucial mechanism in regulating the immune response, setting the balance between immunity and tolerance. Here, we investigated the function of a poorly understood alternative branch of the ubiquitin-activating E1 enzyme UBA6 in activating immune cells.
Ji Yeon Lee +4 more
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Frontiers in Molecular Neuroscience, 2021 Over thirty years have passed since the first description of ubiquitin-positive structures in the brain of patients suffering from Alzheimer’s disease.
Frédéric Ebstein +4 more
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Ubiquitin-Conjugating Enzymes in Cancer
Cells, 2021 The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The
Quyen Thu Bui +4 more
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Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. [PDF]
PLoS ONE, 2013 The ubiquitin-signaling pathway utilizes E1 activating, E2 conjugating, and E3 ligase enzymes to sequentially transfer the small modifier protein ubiquitin to a substrate protein.
Donald E Spratt +2 more
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