Results 21 to 30 of about 59,068 (260)
Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation [PDF]
Cells, 2021 Ubiquitination is a crucial mechanism in regulating the immune response, setting the balance between immunity and tolerance. Here, we investigated the function of a poorly understood alternative branch of the ubiquitin-activating E1 enzyme UBA6 in activating immune cells.
Ji Yeon Lee +4 more
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Homology Modelling of Human E1 Ubiquitin Activating Enzyme [PDF]
Letters in Drug Design & Discovery, 2010 Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
Brahemi, Ghali +3 more
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UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses
Frontiers in Endocrinology, 2023 The UFM1 conjugation system(UFMylation)is a novel type of ubiquitin-like system that plays an indispensable role in maintaining cell homeostasis under various cellular stress.
Qiang Jiang +9 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Over thirty years have passed since the first description of ubiquitin-positive structures in the brain of patients suffering from Alzheimer’s disease.
Frédéric Ebstein +4 more
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TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets
Frontiers in Chemistry, 2019 Protein modification by Ubiquitin or Ubiquitin-like modifiers is mediated by an enzyme cascade composed of E1, E2, and E3 enzymes. E1s, or ubiquitin-activating enzymes, perform ubiquitin activation. Next, ubiquitin is transferred to ubiquitin-conjugating
Daniel Salas-Lloret +2 more
doaj +1 more source
Ubiquitin-Conjugating Enzymes in Cancer
Cells, 2021 The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The
Quyen Thu Bui +4 more
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Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. [PDF]
PLoS ONE, 2013 The ubiquitin-signaling pathway utilizes E1 activating, E2 conjugating, and E3 ligase enzymes to sequentially transfer the small modifier protein ubiquitin to a substrate protein.
Donald E Spratt +2 more
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Synthesis of (di)nucleoside polyphosphates by the ubiquitin activating enzyme E1 [PDF]
FEBS Letters, 2005 Previous work from this laboratory had shown that ligases may catalyze the synthesis of (di)nucleoside polyphosphates. Here, we show that one of the enzymes of the proteasome system (E1 or the ubiquitin (Ub) activating enzyme, EC 6.3.2.19) catalyzes very effectively (k cat = 0.29 ± 0.05 s−1) the transfer of AMP from the E–AMP–ubiquitin complex to ...
Günther Sillero, Maria A. +3 more
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E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang +3 more
doaj +1 more source
Journal of Fungi, 2021 Csn5 is a subunit ofthe COP9/signalosome complex in model fungi. Here, we report heavier accumulation of orthologous Csn5 in the nucleus than in the cytoplasm and its indispensability to insect pathogenicity and virulence-related cellular events of ...
Ya-Ni Mou +4 more
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