Results 81 to 90 of about 1,455 (196)

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss, Maria A. Lizarralde‐Iragorri, Thiago Trovati Maciel, Olivier Hermine   +3 more
wiley   +1 more source

VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation

Nature Communications
Acquired mutations in the UBA1 gene were recently identified in patients with severe adult-onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic). However, the precise physiological and clinical impact of
Olivier Kosmider, Céline Possémé, Marie Templé, Aurélien Corneau, Francesco Carbone, Eugénie Duroyon, Paul Breillat, Twinu-Wilson Chirayath, Bénédicte Oules, Pierre Sohier, Marine Luka, Camille Gobeaux, Estibaliz Lazaro, Roderau Outh, Guillaume Le Guenno, François Lifermann, Marie Berleur, Melchior Le Mene, Chloé Friedrich, Cédric Lenormand, Thierry Weitten, Vivien Guillotin, Barbara Burroni, Jeremy Boussier, Lise Willems, Selim Aractingi, Léa Dionet, Pierre-Louis Tharaux, Béatrice Vergier, Pierre Raynaud, Hang-Korng Ea, Mickael Ménager, Darragh Duffy, Benjamin Terrier   +33 more
doaj   +1 more source

Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort

RMD Open
Objective: To describe the joint manifestations associated with clonal haematopoiesis and to compare patients with and without VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Olivier Vittecoq, Fabrice Jardin, Thierry Lequerre, Ygal Benhamou, Vincent Langlois, Baptiste de Maleprade, Gaetan Sauvetre, Pauline Brevet, Fabien Jastrzebski, Benjamin Membrey, Marine Avenel, Alexandre Curie, Guillaume Armengol, Aspasia Stamatoullas-Bastard   +13 more
doaj   +1 more source

Safety and effectiveness of the combination of 5‐azacitidine and ruxolitinib in VEXAS syndrome: A single‐centre experience

British Journal of Haematology, Volume 208, Issue 3, Page 1133-1137, March 2026.
Gregorio Maria Bergonzi, Enrico Cozzo, Alessandro Tomelleri, Costanza Piccolo, Gianluca Scorpio, Carmelo Gurnari, Francesca Romano, Marco Matucci‐Cerinic, Lorenzo Dagna, Massimo Bernardi, Luca Vago, Fabio Ciceri, Corrado Campochiaro, Elisa Diral   +13 more
wiley   +1 more source

Tissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts

American Journal of Hematology, Volume 100, Issue 12, Page 2305-2319, December 2025.
ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Peter Valent, Johann Wojta, Petri T. Kovanen, Olivier Hermine, Falko Fend, Karl Sotlar, Hildegard Greinix, Klaus Geissler, Karin Hartmann, Juliana Schwaab, Marco Herling, Laura Boccuni, Lukas Kazianka, Max Vincent John, Wolfgang R. Sperr, Carina Zierfuss, Alexandar Tzankov, Christian Sillaber, Milen Minkov, Gregor Hoermann, Matthew Collin, Hans‐Peter Horny, Torsten Haferlach, Maria Sibilia, Julien Haroche, Paul La Rosée, Alberto Orfao, Michel Arock   +27 more
wiley   +1 more source

VEXAS Syndrome: A Comprehensive Review of Clinical Mimickers and Differential Diagnosis at the Rheumatology–Haematology Interface

Journal of Education, Health and Sport
VEXAS syndrome is a newly described autoimmune disorder in adults caused by a somatic mutation in the UBA1 gene located on the X chromosome, occurring almost exclusively in older men.
Hanna Aleksandrowicz, Zuzanna Kalinowska, Julia Sokołowska , Karolina Karska, Katarzyna Grunwald, Marcel Dawidowicz   +5 more
doaj   +1 more source

CO:06:3 | Clinical and laboratory markers for distinguishing VEXAS from Schnitzler's syndrome in male patients with skin involvement: insights from the International AIDA Network Registries

Reumatismo
Background: VEXAS syndrome and Schnitzler’s disease are rare adult-onset autoinflammatory conditions that often present with overlapping clinical and laboratory features, particularly in the early stages.
Società Italiana di Reumatologia
doaj  

Macrocytic Anemia: A Presenting Feature of VEXAS Syndrome

Annals of Internal Medicine: Clinical Cases
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is an X-linked multisystem inflammatory syndrome characterized by a combination of various clinical features, including myeloid dysplasia, sweet syndrome, relapsing polychondritis,
Indira Acharya, Bernadette C. Siaton, Christopher J. Haas   +2 more
doaj   +1 more source

Efficacy and safety profile of biotechnological agents and Janus kinase inhibitors in VEXAS syndrome: data from the international AIDA Network VEXAS registry [PDF]

Background: VEXAS syndrome, a recently identified systemic autoinflammatory disorder, poses new diagnostic and management challenges. Based on experience with other autoinflammatory diseases, anti-interleukin (IL)-1, anti-IL-6, anti-tumor necrosis factor
Araujo O., Baggio C., Balistreri A., Batu E. D., Beecher M., Bindoli S., Bixio R., Caggiano V., Callisto A., Campochiaro C., Cantarini L., Cauli A., Conticini E., Cordeiro R. A., Crisafulli F., D'Agostino M. A., Dagna L., De Paulis A., de-la-Torre A., Fabiani C., Franceschini F., Frassi M., Frediani B., Giardini H. A. M., Gomez-Caverzaschi V., Guaracha-Basanez G. A., Gurnari C., Hernandez-Rodriguez J., Hinojosa-Azaola A., Hissaria P., Iannone F., Jaber N., Kawakami-Campos P. A., Kucuk H., La Torre F., Leone F., Lopalco G., Maher A., Martin-Nares E., Montecucco C., Monti S., Mormile I., Ozen S., Piga M., Portincasa P., Ragab G., Rovera G., Ruiz-Irastorza G., Sfriso P., Sota J., Soto-Peleteiro A., Tomelleri A., Torres-Ruiz J., Triggianese P., Tufan A., Viapiana O., Vitale A., Vitetta R., Wiesik-Szewczyk E.   +58 more
core   +3 more sources

VEXAS Syndrome and Substance Use Disorders: A Large‐Scale, Propensity‐Matched, Case‐Control Analysis Revealing Immune‐Mediated Comorbidities

International Journal of Dermatology, Volume 65, Issue 3, Page 584-586, March 2026.
Kritin K. Verma, Kevin T. Nguyen, Daniel P. Friedmann, Helen Chen, Michelle B. Tarbox   +4 more
wiley   +1 more source