Results 81 to 90 of about 940 (155)

Navigating therapeutic challenges in VEXAS syndrome: exploring IL-6 and JAK inhibitors at the forefront

Molecular Medicine
VEXAS syndrome, an uncommon yet severe autoimmune disorder stemming from a mutation in the UBA1 gene, is the focus of this paper. The overview encompasses its discovery, epidemiological traits, genetic underpinnings, and clinical presentations.
Xiao Xiao Li, Wen Hui Huang, Xiao Bin Yang, Qi Lin Yang, Yu Zheng, Yong Bao Huo, Ting Ting Xie, Cheng Hui Huang, Shui Lian Yu   +8 more
doaj   +1 more source

Understanding Myelodysplasia and Inflammation Through the Lense of VEXAS Syndrome: A Review

Cells
VEXAS syndrome, a monogenic X-linked disorder resulting from mutations in the UBA1 gene, has emerged as a key model for unraveling the links between systemic inflammatory or autoimmune diseases (SIAD) and myelodysplastic syndromes (MD).
Louis Wolff, Leo Caratsch, Lin-Pierre Zhao, Sabine Blum, Denis Comte   +4 more
doaj   +1 more source

What should neurologists expect to observe in relapsing polychondritis and VEXAS?

Frontiers in Immunology
Relapsing polychondritis (RP) and VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) are two clinically overlapping conditions in which neurological complications remain uncommon.
Mickael Bonnan, Quang Tuan Rémy Nguyen, Etienne Crickx, Etienne Crickx   +3 more
doaj   +1 more source

Clinical features of immunodeficiency and severe infection in VEXAS syndrome: a case series

Discover Medicine
Background VEXAS syndrome is a recently described X-linked somatic autoinflammatory syndrome which manifests with exaggerated hyperinflammation, an MDS-like syndrome, and probable immunodeficiency. Objective The objective of this study is to describe the
Justin Smith, Dylan Johnson, Mohammed Osman, Jason Soo, Stephanie Keeling   +4 more
doaj   +1 more source

Azacytidine Treatment for VEXAS Syndrome

HemaSphere, 2021
Raaijmakers, Marc, Hermans, Maud, Aalbers, Anna, Rijken, Melissa, Dalm, Virgil A.S.H., van Daele, Paul, Valk, Peter   +6 more
openaire   +4 more sources

VEXAS Syndrome for the laboratory physician: a case report. [PDF]

Front Immunol
Chen C, Chen M, Chen T, Chen Y, Liu L, Zhu Y, Yi X, He S.   +7 more
europepmc   +1 more source

Hemi-Orolingual Angioedema in a Patient With VEXAS Syndrome. [PDF]

EJHaem
Suárez EU, Arquero-Portero T, Llamas-Sillero P.   +2 more
europepmc   +1 more source

Exploring glucocorticoid dose-response patterns in VEXAS syndrome: a pilot retrospective study. [PDF]

Rheumatol Int
Giachetti N, Hadjadj J, Gaudré N, Lavigne C, Lacombe V.   +4 more
europepmc   +1 more source

Unmasking Vexas Syndrome: A Rare Case with Crescentic Glomerulonephritis. [PDF]

Eur J Case Rep Intern Med
Shah T.
europepmc   +1 more source

Drug-Free Remission of VEXAS Syndrome Without Stem Cell Transplantation. [PDF]

Cureus
Warren J, Smylie C, Milne A.
europepmc   +1 more source