Results 61 to 70 of about 31,788 (164)

Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors.

PLoS Genetics, 2011
Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify disease into molecularly defined subtypes to examine associations with etiologic risk factors and prognosis.
Lee E Moore, Michael L Nickerson, Paul Brennan, Jorge R Toro, Erich Jaeger, Jessica Rinsky, Summer S Han, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Laura S Schmidt, Petra Lenz, Sara Karami, W Marston Linehan, Maria Merino, Stephen Chanock, Paolo Boffetta, Wong-Ho Chow, Frederic M Waldman, Nathaniel Rothman   +24 more
doaj   +1 more source

Integration of scRNA‐Seq and scATAC‐Seq Revealed the Role of lncRNA RP11‐661C8.2 by Promoting EMT in Clear Cell Renal Cell Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Long noncoding RNAs (lncRNAs) play an important role in tumor progression. However, most of the previously discovered lncRNAs that promote or inhibit tumor progression were derived from bulk RNA‐seq results. Data from single‐cell RNA sequencing (scRNA‐seq) and single‐cell assay for transposase‐accessible chromatin using sequencing (scATAC‐seq)
Jizhen Cen, Xuefang Liang, Zheng Wen, Shengzhu Huang, Jiaping Li, Haibiao Yan, Kaiqiang Tang, Guifen Zhou, Ning Liang, Qi Zheng, Cheng Su, Zengnan Mo, Zhenyuan Yu   +12 more
wiley   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas

Biochemistry and Biophysics Reports, 2019
Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Clear cell RCC (ccRCC) accounts for the majority of RCC, which have mutations or epigenetic silencing of the von Hippel–Lindau (VHL) gene.
Hiromi Koma, Yasuhiro Yamamoto, Tomonari Fujita, Tatsurou Yagami   +3 more
doaj   +1 more source

A Case of Von Hippel-Lindau Disease Presented with Multiple Pancreatic Cysts and Medullary Hemangioblastoma

Clinical Pediatric Hematology-Oncology, 2020
Von Hippel-Lindau (VHL) disease is a rare inherited cancer predisposition syndrome characterized by benign and malignant tumors in multiple organs, especially cerebellar hemangioblastomas, retinal angiomas, renal-cell carcinoma, and pheochromocytomas ...
Young Hyun Kim, Hye Lim Jung, Aram Yang, Ji Hee Kwak, Deok Soo Kim, Jung Yeon Shim, Jae Won Shim   +6 more
doaj   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Novel gene mutation in von Hippel-Lindau disease – a report of two cases

BMC Medical Genetics, 2019
Background Von Hippel-Lindau (VHL) syndrome is a familial autosomal dominant hereditary neoplastic disease caused by mutations in the VHL gene. Approximately 503 kinds of VHL gene mutations have been reported.
Jitian Wang, Wenjie Cao, Zhaoxia Wang, Hong Zhu   +3 more
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification.

PLoS ONE, 2010
The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFalpha.
Qiliang Cai, Suhbash C Verma, Pankaj Kumar, Michelle Ma, Erle S Robertson   +4 more
doaj   +1 more source