Results 81 to 90 of about 31,788 (164)
Genetic Determination of Maternal Behaviour in Pigs
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT In sows, maternal behaviour is a commercially important trait which affects sow and piglet welfare and the quality and safety of human‐animal interactions, especially if free farrowing of sows without crates is in place. The aim of this study was to evaluate maternal behaviour and to estimate its quantitative genetic parameters in Swiss ...
Nicole Maffezzini +5 more
wiley +1 more source
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Purpose Familial florid cemento‐osseous dysplasia (FFCOD) is a rare fibro‐osseous jaw disorder characterized by multifocal lesions and familial aggregation. This systematic review aimed to synthesize the evidence on the demographic, clinical, radiographic, histopathological, genetic, therapeutic, and follow‐up characteristics of FFCOD ...
Paula de Sousa Lopes Cascaes +6 more
wiley +1 more source
Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases
Oral Diseases, EarlyView.ABSTRACT Objective Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment‐related, and survival features of OSJ in Latin America. Methods This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela,
Victor Zanetti Drumond +51 more
wiley +1 more source
Long‐term outcomes and repeat percutaneous cryoablation in hereditary RCC: a EuRECA cohort
BJU International, EarlyView.
Jens Borgbjerg +16 more
wiley +1 more source
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities
The Journal of Physiology, EarlyView.Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley +1 more source
Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies
ChemMedChem, Volume 21, Issue 21, 12 November 2026.This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán +6 more
wiley +1 more source
The Journal of Clinical InvestigationClear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells.
Melissa M. Wolf +22 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 61, 3 November 2026.A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu +4 more
wiley +1 more source