Results 111 to 120 of about 1,940,966 (390)
Genomic landscape and preclinical models of angiosarcoma
Molecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton +3 more
wiley +1 more source
Floral herbivory of an invasive slug on a native weed
Plant Protection Science, 2014 Effects of floral herbivory (grazing flowers) by slugs on production and quality of seeds of herbaceous plants have been rarely quantified. We studied consequences of grazing by an invasive slug Arion lusitanicus (Mabille) for inflorescences of dandelion
Alois Honěk, Zdenka Martinková
doaj +1 more source
Stochastic viability and dynamic programming [PDF]
arXiv, 2010 This paper deals with the stochastic control of nonlinear systems in the presence of state and control constraints, for uncertain discrete-time dynamics in finite dimensional spaces. In the deterministic case, the viability kernel is known to play a basic role for the analysis of such problems and the design of viable control feedbacks.
arxiv
Molecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang +6 more
wiley +1 more source
Population viability analysis.
, 2016 To evaluate the viability of the Florida panther population and to complement the habitat suitability analysis, we reviewed previous population viability analyses (PVA) published in the scientific literature, and we developed a new spatially explicit ...
Philip A. Stephens
semanticscholar +1 more source
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Nature Communications, 2016 Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib has been approved for treatment of advanced ovarian cancer associated with BRCA1 and BRCA2 mutations.
Xia Ding +20 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
The Viability of the “Responsibility to Prevent”
Politics and Governance, 2015 The efficacy of the Responsibility to Prevent suffers from two key problems; causal indeterminacy, and a dependence on the political will of states, particularly the permanent five members of the Security Council. The vast array of factors which can be cited as potentially contributing to the outbreak of conflict and atrocity crimes mitigates against ...
openaire +4 more sources