Results 171 to 180 of about 2,440 (209)
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ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Philip J. Stephens +2 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Philip J. Stephens +2 more
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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Here, we present the new application of solid-state Vibrational Circular Dichroism (VCD) spectroscopy to differentiate several dutasteride (DS) solvatomorphs - the model active pharmaceutical ingredient (API). Several crystalline DS hydrochloride hydrates solvated with methanol, ethanol, acetonitrile, acetone, and acetic acid were prepared. In contrast
Joanna E. Rode +2 more
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Here, we present the new application of solid-state Vibrational Circular Dichroism (VCD) spectroscopy to differentiate several dutasteride (DS) solvatomorphs - the model active pharmaceutical ingredient (API). Several crystalline DS hydrochloride hydrates solvated with methanol, ethanol, acetonitrile, acetone, and acetic acid were prepared. In contrast
Joanna E. Rode +2 more
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Helvetica Chimica Acta, 2003
AbstractBiphenyls with only two substituents at the ‘peri'‐position normally show rotation about their chiral axis at room temperature. Using vibrational circular dichroism (VCD), we found no evidence for rotation of (P)‐2′‐[(4S)‐4,5‐dihydro‐4‐(1‐methylethyl)oxazol‐2‐yl][1,1′‐biphenyl]‐2‐methanol ((P,S)‐1) in CDCl3 about its chiral axis due to ...
Teresa B. Freedman +5 more
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AbstractBiphenyls with only two substituents at the ‘peri'‐position normally show rotation about their chiral axis at room temperature. Using vibrational circular dichroism (VCD), we found no evidence for rotation of (P)‐2′‐[(4S)‐4,5‐dihydro‐4‐(1‐methylethyl)oxazol‐2‐yl][1,1′‐biphenyl]‐2‐methanol ((P,S)‐1) in CDCl3 about its chiral axis due to ...
Teresa B. Freedman +5 more
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Chirality, 2009
AbstractThe absolute configuration (AC) of the antiprotozoal lactone, Klaivanolide, 1, from Uvaria klaineana, has been determined using Vibrational Circular Dichroism (VCD) spectroscopy. The experimental VCD spectrum of the (+) enantiomer of 1 was measured.
Frank J, Devlin +2 more
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AbstractThe absolute configuration (AC) of the antiprotozoal lactone, Klaivanolide, 1, from Uvaria klaineana, has been determined using Vibrational Circular Dichroism (VCD) spectroscopy. The experimental VCD spectrum of the (+) enantiomer of 1 was measured.
Frank J, Devlin +2 more
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Molecular Physics, 1988
A general sum rule is given for the rotational strength, Rt , in VCD of chiral molecules with the rotational correction included. It is found that Σ Rl (l = 1 to 3N) may be zero only for isotopically chiral molecules as specified below by analogy with the sum rule given by Cuony and Hug in Raman optical activity (ROA).
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A general sum rule is given for the rotational strength, Rt , in VCD of chiral molecules with the rotational correction included. It is found that Σ Rl (l = 1 to 3N) may be zero only for isotopically chiral molecules as specified below by analogy with the sum rule given by Cuony and Hug in Raman optical activity (ROA).
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Applied Spectroscopy, 2013
Atropisomers exist when axial chirality is present as a result of conformationally restricted rotation around a single bond. The interconversion rate of the individual atropisomers is critical to the assessment of chiral stability of a drug throughout scale-up, development, production, and storage as well as in vivo pharmacokinetics.
Don E, Pivonka, Steven S, Wesolowski
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Atropisomers exist when axial chirality is present as a result of conformationally restricted rotation around a single bond. The interconversion rate of the individual atropisomers is critical to the assessment of chiral stability of a drug throughout scale-up, development, production, and storage as well as in vivo pharmacokinetics.
Don E, Pivonka, Steven S, Wesolowski
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Helvetica Chimica Acta, 2005
Vibrational-circular-dichroism (VCD) studies of the solution conformations of three 2,2′-substituted biphenyls are reported. Biphenyls with only two substituents at the peri-position normally show rotation about their central axis of chirality at room temperature in solution.
Teresa B. Freedman +5 more
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Vibrational-circular-dichroism (VCD) studies of the solution conformations of three 2,2′-substituted biphenyls are reported. Biphenyls with only two substituents at the peri-position normally show rotation about their central axis of chirality at room temperature in solution.
Teresa B. Freedman +5 more
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Vibrational Spectroscopy, 2006
Abstract Near-infrared (near-IR) and mid-infrared (mid-IR) vibrational circular dichroism (VCD) spectra in the region 800–10,000 cm−1 were recorded for nine enantiomeric pairs (or enantiomer and racemate pairs) of molecules with three ChiralIR Fourier transform (FT) VCD spectrometers equipped with various light sources and detectors and modified for ...
Changning Guo +5 more
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Abstract Near-infrared (near-IR) and mid-infrared (mid-IR) vibrational circular dichroism (VCD) spectra in the region 800–10,000 cm−1 were recorded for nine enantiomeric pairs (or enantiomer and racemate pairs) of molecules with three ChiralIR Fourier transform (FT) VCD spectrometers equipped with various light sources and detectors and modified for ...
Changning Guo +5 more
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Applied Spectroscopy, 2014
The chiral configuration of three of the four chiral centers in the investigational drug MLN4924 is locked by an intermediate (1S,2S,4R)-4-amino-2-(hydroxymethyl)cyclopentanol (designated as INT1a). The intermediate INT1a is a key component to the molecule, but its multiple chiral centers and lack of chromophore make it challenging to analyze for ...
Laila, Kott +4 more
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The chiral configuration of three of the four chiral centers in the investigational drug MLN4924 is locked by an intermediate (1S,2S,4R)-4-amino-2-(hydroxymethyl)cyclopentanol (designated as INT1a). The intermediate INT1a is a key component to the molecule, but its multiple chiral centers and lack of chromophore make it challenging to analyze for ...
Laila, Kott +4 more
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Tetrahedron: Asymmetry, 2008
Abstract The (+) and (−) enantiomers of the isotopically chiral sulfoxide, perdeuteriophenyl-phenyl-sulfoxide, 1 , have been synthesized by the reaction of the diastereomers of O -menthyl benzenesulfinate with C 6 D 5 MgBr. Their absolute configurations have been determined by comparison of the vibrational circular dichroism (VCD) spectra of ( R )-
Józef Drabowicz +5 more
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Abstract The (+) and (−) enantiomers of the isotopically chiral sulfoxide, perdeuteriophenyl-phenyl-sulfoxide, 1 , have been synthesized by the reaction of the diastereomers of O -menthyl benzenesulfinate with C 6 D 5 MgBr. Their absolute configurations have been determined by comparison of the vibrational circular dichroism (VCD) spectra of ( R )-
Józef Drabowicz +5 more
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