Results 31 to 40 of about 2,159,524 (206)

Specific Determinants of the Transmembrane Region of the Andes Virus Gc Glycoprotein Drive the Transition from Membrane Hemifusion to Pore Formation

Viruses
Andes virus (ANDV), a highly pathogenic orthohantavirus, enters host cells through low pH–triggered membrane fusion mediated by the Gc glycoprotein, a class II fusion protein containing a single C-terminal transmembrane domain (TMD). While the ectodomain
Chantal L. Márquez, Fernando Villalón-Letelier, Gianina Arata-Salas, Nicole D. Tischler   +3 more
doaj   +1 more source

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Nature Communications, 2019
Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and ...
Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser   +10 more
doaj   +1 more source

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

Frontiers in Aging Neuroscience, 2012
Protein folding occurs in several intracellular locations including the endoplasmic reticulum (ER) and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery.
Sebastián eBernales, Marisol Andrea Morales Soto, Marisol Andrea Morales Soto, Emma eMcCullagh   +3 more
doaj   +1 more source

Socioeconomic status correlates with COVID-19 vaccination coverage among primary and secondary students in the most populated city of Chile

Scientific Reports
The burden of COVID-19 was heterogeneous, indicating that the effects of this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character.
Enzo Guerrero-Araya, Cesar Ravello, Mario Rosemblatt, Tomas Perez-Acle   +3 more
doaj   +1 more source

Proper pandemic preparedness requires an integrated cross-regional effort, the case of the ECLIPSE consortium in America: a narrative review

Journal of Health, Population and Nutrition
Background Emerging and re-emerging infectious diseases pose significant threats to global public health, economic stability, and security. This paper focuses on three critical examples: Highly Pathogenic Avian Influenza (HPAI), Dengue Fever (DF), and ...
Alejandro Bernardin, Tiago Masrour, Brooke Partridge, Alberto J. M. Martin, Alison Kelly, Tomas Perez-Acle   +5 more
doaj   +1 more source

El vitalismo de Gilles Deleuze

Daimon, 2015
El propósito del presente artículo radica en mostrar que el vitalismo de Deleuze, central en su obra, implica una ruptura drástica con la tradición filosófica, ya que su reelaboración conceptual va parejo de un desmontaje de la subsiguiente lógica ...
Julien Canavera
doaj   +1 more source

Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice

Cell Death and Disease
Aging is a progressive process characterized by cellular and molecular damage leading to mitochondrial dysfunction and cognitive decline. Mitochondrial dysfunction is a critical factor in memory impairment in aging and neurodegenerative diseases.
Karina A. Cicali, Claudia Jara, Daniela Cortés-Díaz, Matías Lira, Ítalo Fuentes, Alejandra Catenaccio, Josefa Arnaíz, Micaela Ricca, Sebastián Valenzuela, Carolina A. Oliva, Daniela S. Rivera, Cheril Tapia-Rojas   +11 more
doaj   +1 more source

Vida artista, vida livre

DoisPontos, 2017
O artigo, que trabalha com os textos originais de Foucault, apresenta os vínculos entre os conceitos de ‘vida artista’, ‘estética da existência’ e de ‘resistência ao poder’. Sua hipótese é a de que existe estreito vínculo entre estética, política e liberdade na fase madura(1978-1984) do lósofo francês.
openaire   +2 more sources

Postfemminismo reazionario

, 2020
Il saggio analizza alcuni degli effetti politici, culturali ed economici dell'egemonia culturale esercitata dall'individualità apparentemente neutra e asessuata del soggetto neoliberale per mostrare il carattere "reazionario" del postfemminismo e il ...
Silvia Vida
core   +1 more source

CORRELAÇÃO ENTRE O IMC E AS CAPACIDADES MOTORAS CONDICIONAIS EM JOVENS PRATICANTES DE MODALIDADES DESPORTIVAS EXTRA-CURRICULARES

E-balonmano.com: Revista de Ciencias del Deporte, 2015
As capacidades motoras são “a base para a capacidade de aprendizagem sensorial e motora”, responsáveis pela execução de uma ação, desde a mais simples à mais complexa (andar, correr, etc.) (Moraes, 2003).
C. Alves, J. Mercúrio, J. Cruz, N. Amaro, C. Leitão, L. Coelho   +5 more
doaj   +2 more sources