Results 91 to 100 of about 15,083 (304)

Topiramate in the treatment of severe myoclonic epilepsy in infancy [PDF]

, 2000
The aim of this study was to assess the effectiveness of topiramate (TPM) as an add-on regimen in reducing seizure rate in a population sample of patients diagnosed with severe myoclonic epilepsy in infancy (SME). Eighteen patients were evaluated.
Nieto-Barrera, M, Candau, R, Nieto-Jimenez, M, Correa, A, Ruiz del Portal, L   +4 more
core   +1 more source

Rare dysfunctional SCN2A variants are associated with malformation of cortical development

Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.
Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot, Christopher H. Thompson, Susan Sotardi, Jinan Jiang, Marina Trivisano, Simona Balestrini, D. Isum Ward, Natalie Ginn, Brunetta Guaragni, Laura Malerba, Angeliki Vakrinou, Mia Sherer, Ingo Helbig, Ala Somarowthu, Sanjay M. Sisodiya, Roy Ben‐Shalom, Renzo Guerrini, Nicola Specchio, Alfred L. George Jr, Ethan M. Goldberg   +19 more
wiley   +1 more source

Guideline Update to Treatment of Infantile Spasms

Pediatric Neurology Briefs, 2012
The Guideline Developmental Subcommittee of the AAN and the Practice Committee of the CNS update the 2004 practice parameter on treatment of infantile spasms (IS).
J Gordon Millichap
doaj   +1 more source

Longer Duration of Epilepsy and Earlier Age at Epilepsy Onset Correlate with Impaired Cognitive Development in Infancy [PDF]

, 2009
We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with ...
Vendrame, Martina
core   +2 more sources

Extracting epilepsy‐related information from unstructured clinic letters using large language models

Epilepsia, EarlyView.
Abstract Objective The emergence of large language models (LLMs) and the increasing prevalence of electronic health records (EHRs) present significant opportunities for advancing health care research and practice. However, research that compares and applies LLMs to extract key epilepsy‐related information from unstructured medical free text is under ...
Shichao Fang, Ben Holgate, Anthony Shek, Joel S. Winston, Matthew McWilliam, Pedro F. Viana, James T. Teo, Mark P. Richardson   +7 more
wiley   +1 more source

Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse

Annals of Clinical and Translational Neurology, 2015
Recent findings in mice with targeted deletion of the GABA‐metabolic enzyme succinic semialdehyde dehydrogenase revealed a new role for supraphysiological GABA (4‐aminobutyric acid) in the activation of the mechanistic target of rapamycin (mTOR) that ...
K. Vogel, G. Ainslie, E. Jansen, G. Salomons, K. Gibson   +4 more
semanticscholar   +1 more source

Long‐term efficacy and safety of cannabidiol in patients with treatment‐resistant focal epilepsies treated in the Expanded Access Program

Epilepsia, EarlyView.
Open‐label CBD treatment was associated with sustained seizure reduction through 144 weeks, with a consistent safety profile in patients with treatment‐resistant focal epilepsies, regardless of epilepsy type. Abstract Objective Cannabidiol (CBD) treatment was associated with long‐term seizure reduction in patients with various treatment‐resistant ...
Anup D. Patel, Jerzy P. Szaflarski, Paul D. Lyons, Michael Boffa, Teresa Greco, Timothy B. Saurer, Karthik Rajasekaran, Kelly C. Simontacchi, Elizabeth A. Thiele   +8 more
wiley   +1 more source

UK Multicenter Randomized Trial of Hormonal Treatments Vs Vigabatrin for Infantile Spasms

Pediatric Neurology Briefs, 2010
The UK Infantile Spasms Multicenter Study previously showed that seizure control after 14 days and development at 14 months are better following hormonal treatments (prednisolone or tetracosactide depot) than following vigabatrin.
J Gordon Millichap
doaj   +1 more source

Trends in long-term prescribing of dependence forming medicines [PDF]

, 2019
Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S., Nguyen, A., Sehmi, R., Smith, N.   +3 more
core  

Tuberous Sclerosis Complex (TSC): Expert Recommendations for Provision of Coordinated Care. [PDF]

, 2019
Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem genetic disorder characterized by benign tumors in multiple organs, including the skin, brain, kidneys, and lungs and occasional malignant tumors.
Adriaensen, Amin, Bissler, Black, Bombardieri, Breckenridge, Capal, Crino, Curatolo, Curatolo, Curatolo, Curatolo, De Vries, Franz, French, Jansen, Jansen, Johnson, Jóźwiak, Jóźwiak, Jóźwiak, Kingswood, Kingswood, Kingswood, Koenig, Krueger, Northrup, O'Callaghan, Roth, Sampson, Shepherd, Whitney, Wu   +32 more
core   +5 more sources