Results 71 to 80 of about 7,079 (166)

UK Multicenter Randomized Trial of Hormonal Treatments Vs Vigabatrin for Infantile Spasms

Pediatric Neurology Briefs, 2010
The UK Infantile Spasms Multicenter Study previously showed that seizure control after 14 days and development at 14 months are better following hormonal treatments (prednisolone or tetracosactide depot) than following vigabatrin.
J Gordon Millichap
doaj   +1 more source

Utility of repeat stereotactic EEG in pediatric patients with tuberous sclerosis

Epilepsia Open, EarlyView.
Abstract Objective Tuberous sclerosis complex (TSC) is a rare genetic disorder associated with early‐onset drug‐resistant epilepsy (DRE) secondary to intracranial tubers. Many patients undergo stereo‐EEG (sEEG) for seizure onset localization, sometimes requiring multiple sEEGs and subsequent epilepsy surgeries. Our objective was to evaluate the effects
Julie Uchitel, Olubunmi Fariyike, Samantha Steeman, Sarah Rockwood, Lily H. Kim, John Choi, Astrid C. Hengartner, Aiden H. Fel, Prathyusha Teeyagura, Gerald Grant, Vivek Buch, Kelly B. Mahaney, Laura M. Prolo, Ann Hyslop Segeren, H. Westley Phillips   +14 more
wiley   +1 more source

Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding

Neuropsychiatric Disease and Treatment, 2008
Luisa RochaPharmacobiology Department, Center for Research and Advanced Studies, Calz, Tenorios, MéxicoAbstract: Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days ...
Luisa Rocha
doaj  

Real‐world use of Cenobamate in pediatric drug‐resistant epilepsy: A European multicenter retrospective study

Epilepsia Open, EarlyView.
Abstract Pediatric drug‐resistant epilepsy (DRE) remains a significant clinical challenge, with few effective pharmacological options. This European multicenter retrospective study assessed the real‐world efficacy, tolerability, and retention of off‐label cenobamate (CNB) in 108 children and adolescents with DRE (median age: 13.83 years, range 3.9–19.8)
Konstantin L. Makridis, Thomas Bast, Stéphane Auvin, Pavel Krsek, Matyas Ebel, Eva Breuer, Mira Beckhaus, Matúš Bašovský, Pavlína Danhofer, Ondřej Horák, Alessandro Orsini, Gonzalo Alonso Ramos Rivera, Hana Medřická, Steffen Syrbe, Angela M. Kaindl   +14 more
wiley   +1 more source

Vigabatrin monotherapy in resistant neonatal seizures [PDF]

, 1995
Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy.
Livingston, J., Murdoch-Eaton, D., Gardner-Medwin, D., Baxter, P.S., Barwick, D.D., Ince, P.   +5 more
core   +1 more source

Infantile Spasms Consensus Report

Pediatric Neurology Briefs, 2010
An Infantile Spasms Working Group (ISWG) of 14 pediatric neurologists with expertise in IS participated in a 2-day workshop to discuss 1) the current state of IS management, 2) the evidence for efficacy of ACTH and vigabatrin (VGB), approved in the US in
J Gordon Millichap
doaj   +1 more source

Peripheral retinal dysfunction in patients taking vigabatrin

, 2003
Objective: To assess the wide-field multifocal electroretinogram (WF-mfERG) for assessment of retinal function in vigabatrin-treated patients. Methods: Thirty-two adults who had taken vigabatrin for at least 3 years for localization-related epilepsy ...
Keating, D., McDonagh, J., Parks, S., Dutton, G.N., Sills, G.J., Dolan, F.M., Kelly, K., Stephen, L.J., Stephen, L. J., Brodie, M.J., Sills, G. J.   +10 more
core   +1 more source

Vigabatrin: longterm follow-up of electrophysiology and visual field examinations

, 2003
Background: To report the results of repeated electrophysiological and visual field examinations in patients with vigabatrin-associated visual field loss (VGB-VFL) and the relationship between these electrophysiological findings, the cumulative dose of ...
Stilma, J, Willem Verduin, Hardus, P, Berendschot, T, Peter Hardus, Jan Stilma, Tos Berendschot, Verduin, W, Cees Van Veelen, Gina Postma, van Veelen, C, Postma, G   +11 more
core   +1 more source

Musicogenic Epilepsy in An Infant

Pediatric Neurology Briefs, 2003
A 6-month-old infant with seizures triggered by loud music, especially specific songs of the Beatles, is reported from Chang Gung Children’s Hospital at Linkou, Taoyuan, Taiwan.
J Gordon Millichap
doaj   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source