Results 61 to 70 of about 7,079 (166)
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Developmental Outcomes of Infants Treated With Combination Therapy for Infantile Spasms
Pediatric Neurology Briefs, 2019 The International Collaborative Infantile Spasms Study (ICISS) Group evaluated the developmental and epilepsy outcomes at 18 months following hormonal treatment alone or hormonal treatment combined with vigabatrin.
Jacqueline Wolak, Sunita N Misra
doaj +1 more source
Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future
Epilepsia Open, EarlyView.Abstract Electroencephalography (EEG) has evolved into an indispensable tool in pediatric epilepsy, fundamentally transforming the diagnosis, classification, and management of this condition. This review chronicles the historical journey of EEG from its groundbreaking inception to its current pivotal role in delineating distinct pediatric epilepsy ...
Hiroki Nariai
wiley +1 more source
Psychoses and Epilepsy: Paradoxical Normalization
Pediatric Neurology Briefs, 1994 Five children aged 2.5 to 9 years who developed paradoxical, or forced normalization (acute psychiatric symptoms with abrupt cessation of seizures and normalized EEG) are reported from the Shaare Zedek Medical Center, Jerusalem.
J Gordon Millichap
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
Guideline Update to Treatment of Infantile Spasms
Pediatric Neurology Briefs, 2012 The Guideline Developmental Subcommittee of the AAN and the Practice Committee of the CNS update the 2004 practice parameter on treatment of infantile spasms (IS).
J Gordon Millichap
doaj +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Vigabatrin Toxicity Mimicking Bilateral Thalamic Strokes [PDF]
, 2023 A 20-month-old female with past medical history of tuberous sclerosis, epilepsy and infantile spams treated with vigabatrin presented for surveillance Magnetic Resonance Imaging (MRI) for multiple brain hamartomatous lesions and subependymal nodules. MRI
Lockard, Trevor, Rathore, Geetanjali
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Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
, 1999 BACKGROUND: Vigabatrin is a newly licensed drug for use in patients with epilepsy. We investigated whether this drug was comparable to standard first-line monotherapy in efficacy and incidence of adverse events.
for the Vigabatrin European Monotherapy Study Group +2 more
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