Results 91 to 100 of about 3,513 (158)

Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database

BMC Pharmacology and Toxicology
Background Belatacept is a co-stimulation blocker used in kidney transplant recipients to prevent allograft rejection. Unlike calcineurin inhibitors, belatacept is non-nephrotoxic and may carry a lower risk of cardiovascular and metabolic complications ...
Alexandre O. Gérard, Diane Merino, Nouha Ben Othman, Alexandre Destere, Delphine Viard, Elliot Ewig, Fanny Rocher, Antoine Sicard, Milou-Daniel Drici   +8 more
doaj   +1 more source

Le mésusage des antipsychotiques de seconde génération : une approche à l’aide de la base mondiale de pharmacovigilance, Vigibase™

, 2018
Depuis l’avènement des antipsychotiques de seconde génération (SGAPs), les ventes de ses médicaments ont sans cesse augmenté. D’origine multifactorielle, cette augmentation est liée à celle du mésusage de ces médicaments avec en premier lieu une ...
Charreteur, Robin
core  

The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase

International Journal of Infectious Diseases
Objectives: This study aimed to identify and analyze potential cases of antibiotic resistance in a global pharmacovigilance database. Methods: A search of VigiBase, the World Health Organization global database of adverse event reports, was done on data ...
Joseph Mitchell, Camilla Westerberg, Manju Purohit, Pinelopi Lundquist, Cecilia Stålsby Lundborg   +4 more
doaj   +1 more source

Characterizing pharmacobezoar formation: a descriptive analysis from VigiBase

Introduction: Pharmacobezoars are concretions of drugs that can persist within the gastrointestinal tract and can lead to mechanical obstruction and pharmacological toxicity.
Nicoletta Luxi, Massimo Carollo, Salvatore Crisafulli   +2 more
core   +1 more source

Medication errors in malaria management in children: insights from pharmacovigilance data in the Democratic Republic of Congo

BMC Pharmacology and Toxicology
Introduction Since 2012, DRC adopted WHO recommendations for the malaria treatment with artemisinin-based drugs. Medication errors are defined as “a failure in the treatment process that results in, or has the potential to result in, harm to the patient”.
Mireille Ngale Amba, Erick Kamangu Ntambwe, Aline Engo Biongo, Nsengi Ntamabyaliro, Gauthier Mesia Kahunu, Joseph Bodi Mabiala, Celestin Nsibu Ndosimao, Gaston Tona Lutete, Ghada Miremont-Salamé, Annie Fourrier-Réglat   +9 more
doaj   +1 more source

Analysis of Adverse Reactions Associated with the Use of Crataegus-Containing Herbal Products

Pharmaceuticals
Background/Objectives: Products from various parts of Crataegus species are traditionally applied as a cardiotonic. In Europe and the USA, mainly Crataegus monogyna Jacq.
Herman J. Woerdenbag, Melissa Ursidae, Corine Ekhart, Martina Schmidt, Annabella Vitalone, Florence P. A. M. van Hunsel   +5 more
doaj   +1 more source

Differences in hypersensitivity reactions and gadolinium deposition disease/symptoms associated with gadolinium exposure to gadolinium-based contrast agents: new insights based on global databases VigiBase, FAERS, and IQVIA-MIDAS

BMC Medicine
Background Hypersensitivity reactions (HSRs) can occur unexpectedly and be life-threatening when gadolinium-based contrast agents (GBCAs) are used. Gadolinium deposition disease (GDD) and symptoms associated with gadolinium exposure (SAGE) have been ...
Han Qu, Wenjing Li, Zhenghua Wu, Yuanyuan Wang, Tingting Feng, Nianyun Li, Chendong Qi, Xiang Li, Taishan Wei, Guorong Fan, Yuefen Lou   +10 more
doaj   +1 more source

A Review of COVID-19 Vaccine Adverse Event Following Immunization Case Reports by four CARICOM Countries to VigiBase

The World Health Organization declared COVID-19 a pandemic on 12 March 2020. One of the strategies to combat the pandemic was the development of novel COVID-19 vaccines. Once these vaccines were deployed, immunizations followed.
Marin, Danini
core   +1 more source

A comprehensive atlas of pediatric immune checkpoint inhibitors‐related adverse events: From real‐world pharmacovigilance data to mechanistic insights

Clinical and Translational Discovery
Background Immune checkpoint inhibitors (ICIs) are widely used in childhood cancer, posing challenges with associated ICIs‐related adverse events (irAEs). This study focuses on pediatric irAEs and explores underlying mechanisms.
Anqi Lin, Junyi Shen, Zhenyu Xie, Quan Cheng, Jian Zhang, Peng Luo   +5 more
doaj   +1 more source

Fractures Associated with Immune Checkpoint Inhibitors: A Disproportionality Analysis of the World Health Organization Pharmacovigilance Database

Pharmaceuticals
Background/Objectives: The risk of fractures associated with immune checkpoint inhibitors (ICIs) is increasing; however, the relationship between fracture risk and potential factors, such as osteoporosis and hyperthyroidism, remains unclear.
Takenao Koseki, Hirofumi Hamano, Masakazu Hatano, Takao Tobe, Ryo Ieda, Tsuyoshi Nakai, Yoshito Zamami, Shigeki Yamada   +7 more
doaj   +1 more source