Results 41 to 50 of about 3,513 (158)

The safety of cardioselective β1-blockers in asthma: literature review and search of global pharmacovigilance safety reports

ERJ Open Research, 2021
Introduction Beta-blockers are key in the management of cardiovascular diseases but blocking airway β2-receptors can cause severe and sometimes fatal bronchoconstriction in people with asthma.
Miriam Bennett, Catherina L. Chang, Michael Tatley, Ruth Savage, Robert J. Hancox   +4 more
doaj   +1 more source

Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase. [PDF]

Ther Adv Psychopharmacol
Background: Clozapine is associated with a high risk of central nervous system abnormalities. However, seizure risk related to interactions between clozapine and other antipsychotics remains poorly characterized ...
Hatano M, Hamano H, Kanda M, Koseki T, Nakai T, Horii R, Yoshihara N, Saito T, Takechi K, Esumi S, Zamami Y, Yamada S.   +11 more
europepmc   +2 more sources

Characterization of VigiBase reports on tinnitus associated with bisoprolol—An exploratory and descriptive study

, 2021
The aim of this descriptive and explorative study was to assess individual case safety reports of bisoprolol associated with tinnitus and investigate their added value in information about adverse drug reactions (ADRs) in relation to information provided
Watson, Sarah, Marian Attalla, Elenor Kaminsky, Henric Taavola, Kaminsky, Elenor, Taavola, Henric, Taavola, Henric,, Watson, Sarah,, Quin‐Ying Yue, Attalla, Marian, Yue, Quin-Ying, Kaminsky, Elenor,, Sarah Watson, Attalla, Marian,, Yue, Quin-Ying,   +14 more
core   +1 more source

Immune Checkpoint Inhibitors and Pregnancy: Analysis of the VigiBase® Spontaneous Reporting System [PDF]

, 2022
In pregnancy, immune checkpoint pathways are involved in the maintenance of fetomaternal immune tolerance. Preclinical studies have shown that immune checkpoint inhibitors (ICIs) increase the risk of fetal death.
Laura Müller, Alessandro Ceschi, Roberta Noseda, Müller, Laura, Michele Fusaroli, Francesca Bedussi, Bedussi, Francesca, Fusaroli, Michele, Ceschi, Alessandro, Raschi, Emanuel, Noseda, Roberta, Emanuel Raschi   +11 more
core   +3 more sources

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(®) [PDF]

, 2016
INTRODUCTION Herbal medicines are used worldwide and with an increasing popularity in Western countries. Although often perceived as 'naturally safe', herbals may cause severe adverse drug reactions (ADRs), with immediate allergic reactions being ...
Meyboom, Ronald H B, Russmann, Stefan, Meincke, Ricarda, Pokladnikova, Jitka, Niedrig, David   +4 more
core   +1 more source

International Drug Safety Monitoring

Безопасность и риск фармакотерапии, 2019
In the 1960s, following the Thalidomide Disaster, the World Health Organization (WHO) initiated the development of an international drug safety monitoring programme.
A. S. Kazakov, E. V. Shubnikova, M. A. Darmostukova, I. I. Snegireva, G. V. Kutekhova, K. E. Zatolochina, N. Yu. Velts, D. A. Kaperko, Yu. V. Olefir   +8 more
doaj   +1 more source

Late cardiac adverse events in patients with cancer treated with immune checkpoint inhibitors

Journal for ImmunoTherapy of Cancer, 2020
Background Immune checkpoint inhibitor (ICI)-associated early cardiac adverse events (CAEs), mostly acute and fulminant myocarditis, have been well characterized and mainly occur during the first 90 days after ICI therapy initiation.
Charles Dolladille, Joachim Alexandre, Radj Gervais, Stéphane Allouche, Querntin Dupas, Jeannick Madelaine, Anne-Flore Plane, Francois Comoz, Ariel Aron Cohen, Franck Roland Thuny   +9 more
doaj   +1 more source

Graft Versus Host Disease Associated with Immune Checkpoint Inhibitors: A Pharmacovigilance Study and Systematic Literature Review

Frontiers in Pharmacology, 2021
Background: In patients with allogenic hematopoietic stem cell transplantation (allo-HSCT), immune-checkpoint inhibitors (ICI) are used to treat malignancy recurrence. However, ICI are also associated with graft vs. host disease (GVHD).
Lee S. Nguyen, Lee S. Nguyen, Lisa Raia, Bénédicte Lebrun-Vignes, Bénédicte Lebrun-Vignes, Joe-Elie Salem, Joe-Elie Salem   +6 more
doaj   +1 more source

Spontaneous reports of adverse reactions to methotrexate: retrospective analysis in the Russian Federation

Фармакоэкономика
Background. Methotrexate (MTX) is a widely prescribed medication known for its pronounced anti-inflammatory and anti-tumor effects. However, its use is associated with risks of adverse drug reactions (ADRs) including gastrointestinal tract, infectious ...
S. A. Stefanova, Ya. D. Belousova, V. V. Rafalskiy   +2 more
doaj   +1 more source

Evidence-based methodology for identifying drugs with potential human liver toxicities using WHO Vigibase data

, 2018
Evidence-based methodology for analyzing adverse events related to Drug-Induced Liver Injury (DILI) in WHO Vigibase, a database of Adverse Drug Reactions (ADRs).This document is a protocol for analysis of adverse drug reaction reporting Vigibase data, in
Dirven, Hubert (8148318), Mehta, Jyotsna (8224872), Tsaioun, Katya, Mehta, Jyotsna, Dirven, Hubert, Tsaioun, Katya (8148312)   +5 more
core   +1 more source