Results 61 to 70 of about 3,513 (158)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Adverse drug reactions of cannabis and cannabinoids reported in the international pharmacovigilance database Vigibase®

, 2021
International audienceIntroduction: Data on the potential risks associated with the use of cannabis or cannabinoid derivatives are a cause for concern.
Lapeyre-Mestre, Maryse, Jouanjus, Emilie, Déguilhem, Amélia, Merad, Sonia   +3 more
core   +1 more source

Infections associated with clozapine: a pharmacovigilance study using VigiBase®

, 2023
International audienceIntroduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use.
Chretien, Basile, Sassier, Marion, Dolladille, Charles, Fedrizzi, Sophie, da Silva, Angelique, Brazo, Perrine, Lelong-Boulouard, Veronique, Alexandre, Joachim   +7 more
core   +1 more source

Immune checkpoint inhibitor‐induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1702-1712, October 2026.
A comprehensive retrospective analysis of 121 immune checkpoint inhibitor‐induced eosinophilic fasciitis cases, including clinical presentation, diagnostic features and treatment outcomes using data from the EADV Task Force ‘Dermatology for Cancer Patients’, two international pharmacovigilance databases and the current literature.
Tristan V. M. Bruijn, Alexandre O. Gérard, Maëlys Labat, Zoe Apalla, Wouter van Binsbergen, Dimitra Koumaki, Valerian Rivet, Frederic Dezoteux, Damien Giacchero, Michael R. Ardern‐Jones, Kara Heelan, Jesse P. Hirner, Ander Mayor, Mariette Labots, Markus V. Starink, Conny J. van der Laken, Vincent Sibaud, Yannick S. Elshot   +17 more
wiley   +1 more source

Differences in VigiBase® reporting of aminoglycoside and capreomycin-suspected ototoxicity during tuberculosis treatment [PDF]

, 2017
PURPOSE: To evaluate the association between the use of streptomycin, amikacin, kanamycin and capreomycin in tuberculosis (TB) treatment and the pharmacovigilance reporting of ototoxicity (deafness or hearing loss, tinnitus and vertigo).
Mantel-Teeuwisse, Aukje K, Leufkens, Hubert G M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Souverein, Patrick C, Sagwa, Evans L, Ribeiro, Inês   +6 more
core   +2 more sources

Blood glucose related adverse drug reaction of antitumor monoclonal antibodies: a retrospective analysis using Vigibase

, 2023
On the increasing prevalence of using mAbs (monoclonal antibodies) in cancer therapy and the severe risk of hyperglycemia, we aimed to analyze the main clinical ADRs of mAbs, with a focus on adverse hyperglycemic events associated with currently ...
Lianzhen Chen, Yang, Jincheng
core   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, Volume 104, Issue 6, Page e599-e614, September 2026.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Tramadol-induced hiccups: a case–noncase study in the European pharmacovigilance database

Therapeutic Advances in Drug Safety, 2021
Background: Hiccups are usually benign and self-limiting, but can sometimes be persistent. If left untreated, they can provoke severe discomfort, and even death. Hiccups can be idiopathic, organic, psychogenic, and caused by drugs.
Montserrat García, Unax Lertxundi, Carmelo Aguirre   +2 more
doaj   +1 more source

Blood glucose related adverse drug reaction of antitumor monoclonal antibodies: a retrospective analysis using Vigibase

, 2022
On the increasing prevalence of using mAbs (monoclonal antibodies) in cancer therapy and the severe risk of hyperglycemia, we aimed to analyze the main clinical ADRs of mAbs, with a focus on adverse hyperglycemic events associated with currently ...
Haiyan Zhou (405123), Jincheng Yang (369041), Bei Jia (437864), Bin Zhao (276445), Lianzhen Chen (4993883)   +4 more
core   +1 more source

Amoxicillin and Risk of Hearing Loss: Analysis of Reported Cases Submitted to the WHO Global Database

Drug, Healthcare and Patient Safety, 2020
Mulugeta Russom,1 Aziza Afendi,1 Amon Solomon Ghebrenegus1,2 1Eritrean Pharmacovigilance Centre, National Medicines and Food Administration, Asmara, Eritrea; 2Biet-Mekae Community Hospital, Asmara, EritreaCorrespondence: Mulugeta RussomEritrean ...
Russom M, Afendi A, Ghebrenegus AS
doaj