Results 41 to 50 of about 21,278 (265)

Total and Cause-Specific Mortality After Percutaneous Coronary Intervention: Observations From the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease Registry

CJC Open, 2019
Background: Patients undergoing percutaneous coronary intervention (PCI) are increasingly older and have a higher comorbidity burden. This study evaluated trends in 30-day, 1-year, and 2-year total and cause-specific mortality using a large, contemporary
Dat T. Tran, PhD, Walid Barake, MD, Diane Galbraith, BN, MSc, Colleen Norris, PhD, Merril L. Knudtson, MD, FRCPC, Padma Kaul, PhD, Finlay A. McAlister, MD, PhD, Roopinder K. Sandhu, MD, MPH   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Geographic region variation in patient characteristics, clinical outcomes and treatment of HFrEF in the VICTORIA trial

ESC Heart Failure
Aims Heterogeneity in demographics, aetiology, healthcare access and guideline‐directed medical therapy (GDMT), and survival bias of patients with heart failure with reduced ejection fraction (HFrEF) is evident from international trials and registries ...
Cynthia M. Westerhout, Wendimagegn Alemayehu, Alain Cohen‐Solal, Carolyn S. P. Lam, Justin A. Ezekowitz, Stefano Corda, Ciaran J. McMullan, Christopher M. O'Connor, Paul W. Armstrong, for the VICTORIA Study Group   +9 more
doaj   +1 more source

Dependence of the legume seeds vigour on their maturity and method of harvest

Acta Societatis Botanicorum Poloniae, 2014
Several methods were used to study 'the vigour and viability of legume seeds (Pisum sativum L. cv. Hamil, Piston arvense L. cv. Mazurska and Lupinus luteus L. cv. Tomik) harvested at three main stages of seed repening (green, wax and full).
Stanisław Grzesiuk, Ryszard Górecki
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Viability and vigour of ageing winter wheat grains

Acta Societatis Botanicorum Poloniae, 2014
The viability and vigour of ageing winter wheat caryopses of the cvs. Grana and Jana were tested. Viability was determined on the basis of germination capacity and rate, and vigour on the basis of the over-all activity of hydrogenases in the sprouts ...
Stanisław Grzesiuk, Janusz Tłuczkiewicz   +1 more
doaj   +1 more source

Influence of the practice of physical exercise and healthy eating on the Vigour of university lectures

Frontiers in Sports and Active Living, 2023
IntroductionVigour at work is characterized by high levels of energy and high desire to make an effort at work. This article is the result of a research carried out with university teachers in Spain whose main objective is to show what type and frequency
Montserrat Monserrat Hernández, Ángeles Arjona Garrido, Juan Carlos Checa Olmos, Antonio Casimiro Andújar, Eva María Artés Rodríguez, Darío Salguero García   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source