Results 71 to 80 of about 21,278 (265)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Influence of hydrogel on germination of lettuce and onion seed at different moisture levels
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 The influence of Agrisorb (water solution 1, 3, 5 g/l) on lettuce and onion seed germination was tested in different moisture conditions (30 ml and 15 ml of water in germination box).
Kateřina Pazderů, Martin Koudela
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Folia Horticulturae, 2015 A study of 13 grapevine cultivars was carried out in a vineyard located near Krakow (Poland) in order to identify the most suitable grapevine cultivars for cool climate regions.
Gąstoł Maciej
doaj +1 more source
Apple rootstock trials at Warsaw University of Life Sciences-SGGW, Poland
Horticultural Science, 2018 valuation of 22 dwarfing and semi-dwarfing apple rootstocks for several scion cultivars was conducted on fertile soil in the years 1995-2010. It was found that most of the new rootstocks performed similarly to M.9 EMLA with respect to vigour, yield ...
Cezary Piestrzeniewicz +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Indian Journal of Agricultural SciencesThe study was carried out during summer seasons of 2021 and 2022 at ICAR-National Bureau of Plant Genetic Resources, New Delhi to evaluate 200 ridge gourd [Luffa acutangula (L.) Roxb.] germplasm accessions from India’s national genebank for 14 ...
MONIKA JHA +4 more
doaj +1 more source
Barley seed sensitivity to water stress at germination stage
Plant, Soil and Environment, 2002 Barley seed sensitivity to water and anoxia was tested. Standard germination, mean time of germination (MTG), germination in sand wetted by water to 100% water capacity (anoxia) or by hydrogen peroxide (wet conditions without anoxia), germination in 0.75%
V. Hosnedl, H. Honsová
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
OENO One, 1999 The influence of grapevine water status on vine physiological mecanisms and vigour, as well as on berry ripening and wine characteristics, was studied during the summer of 1997 in the Nemea vine growing area (Peloponnesus, Greece).
Stefanos Koundouras +3 more
doaj +1 more source