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Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang's main component

Chemico-Biological Interactions, 2006
Mitochondrial permeability transition (MPT) is a Ca(2+)-dependent, cyclosporin A (CsA)-sensitive, non-selective inner membrane permeabilization process. It is often associated with apoptotic cell death, and is induced by a wide range of agents or conditions, usually involving reactive oxygen species (ROS).
Gilberto L, Pardo-Andreu   +6 more
openaire   +2 more sources

Vascular effects of the Mangifera indica L. extract (Vimang)

European Journal of Pharmacology, 2004
The effects of the Mangiferia indica L. (Vimang) extract, and mangiferin (a C-glucosylxanthone of Vimang) on the inducible isoforms of cyclooxygenase (cyclooxygenase-2) and nitric oxide synthase (iNOS) expression and on vasoconstrictor responses were investigated in vascular smooth muscle cells and mesenteric resistance arteries, respectively, from ...
Amada E, Beltrán   +7 more
openaire   +2 more sources

PREVENTING HEPATOCYTE OXIDATIVE STRESS CYTOTOXICITY WITH Mangifera indica L. EXTRACT (VIMANG)

Drug Metabolism and Drug Interactions, 2005
Vimang is an aqueous extract of Mangifera indica used in Cuba to improve the quality of life in patients suffering from inflammatory diseases. In the present study we evaluated the effects of Vimang at preventing reactive oxygen species (ROS) formation and lipid peroxidation in intact isolated rat hepatocytes.
Diadelis, Remirez   +4 more
openaire   +2 more sources

Modulation of eosinophil generation and migration by Mangifera indica L. extract (Vimang®)

International Immunopharmacology, 2006
The effects of Vimang, an aqueous extract of the stem bark of Mangifera indica L. (Anacardiaceae), on cell migration in an experimental model of asthma was investigated. In vivo treatment of Toxocara canis-infected BALB/c mice for 18 days with 50 mg/kg Vimang reduced eosinophil migration into the bronchoalveolar space and peritoneal cavity.
Sa-Nunes, Anderson   +7 more
openaire   +3 more sources

Mangifera indica L. (Vimang) Protection against Serum Oxidative Stress in Elderly Humans

Archives of Medical Research, 2006
We searched for the protective effect of a natural extract from stem bark of Mangifera indica L. extract (Vimang) on age-related oxidative stress.Healthy subjects were classified in two groups, elderly (>65 years) and young group (
Gilberto L, Pardo-Andreu   +6 more
openaire   +2 more sources

Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses

Phytotherapy Research, 2003
AbstractThe present study investigated the effects of orally administered Vimang (an aqueous extract of Mangifera indica) and mangiferin (the major polyphenol present in Vimang) on mouse antibody responses induced by inoculation with spores of microsporidian parasites.
D, García   +4 more
openaire   +2 more sources

Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang)

Phytotherapy Research, 2000
An extract of Mangifera indica L. (Vimang) was tested in vitro for its antioxidant activity using commonly accepted assays. It showed a powerful scavenger activity of hydroxyl radicals and hypochlorous acid and acted as an iron chelator. The extract also showed a significant inhibitory effect on the peroxidation of rat-brain phospholipid and inhibited ...
G, Martínez   +5 more
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Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin

International Immunopharmacology, 2002
Vimang is an aqueous extract of Mangiferia indica L., traditionally used in Cuba as an anti-inflammatory, analgesic and antioxidant. In the present study, we investigated the effects of Vimang and of mangiferin (a C-glucosylxanthone present in the extract) on rat macrophage functions including phagocytic activity and the respiratory burst.
D, García   +3 more
openaire   +2 more sources

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