Results 101 to 110 of about 120,449 (305)

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Phase 2 study of hyper‐CMAD with liposomal vincristine for patients with newly diagnosed acute lymphoblastic leukemia [PDF]

, 2020
Koji Sasaki, Hagop M. Kantarjian, William G. Wierda, Farhad Ravandi‐Kashani, Jeffrey L. Jorgensen, Sa A. Wang, Joseph D. Khoury, Naval Daver, Jan A. Burger, Courtney D. Di Nardo, Nitin Jain, Nicholas J. Short, Zeev Estrov, Marina Konopleva, Maro Ohanian, Guillermo Garcia‐Manero, Tapan M. Kadia, Yesid Alvarado‐Valero, Musa Yılmaz, Sherry Pierce, Rebecca Garris, April Ingram, Jörge E. Cortes, Susan O’Brien, Elias Jabbour   +24 more
openalex   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Cisplatin-based chemotherapy of testicular cancer - Two decades after a major breakthrough [PDF]

, 2000
Two decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer, At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard ...
Gerl, Arthur
core   +1 more source

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Acta Veterinaria, 2015
A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological
Pedro PINCZOWSKI, Marina GIMENO, Carmen ACEÑA, Ainara VILLEGAS, Alba de MARTINO, Lluís LUJÁN   +5 more
doaj   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia [PDF]

, 2008
Gudmar Lönnerholm, Britt‐Marie Frost, Jonas Abrahamsson, Mikael Behrendtz, Anders Castor, Erik Forestier, Mats Heyman, Donald R. A. Uges, Siebold S.N. de Graaf   +8 more
openalex   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source