Results 141 to 150 of about 120,449 (305)

Immune‐related toxicity profile after haematopoietic stem cell transplantation in patients with B‐ALL given combination immunotherapy with rituximab, inotuzumab and blinatumomab

open access: yes
British Journal of Haematology, EarlyView.
Olayinka Okeleji   +7 more
wiley   +1 more source

Concurrent ANNPE and vertebral T‐cell lymphoma in a dog: A case report

open access: yesJournal of Small Animal Practice, EarlyView.
Acute non‐compressive nucleus pulposus extrusion (ANNPE) is a recognised cause of peracute spinal cord injury in dogs, involving sudden extrusion of non‐degenerated nucleus pulposus with minimal compression. While often linked to vigorous activity, its triggers remain unclear.
A. Mondino   +5 more
wiley   +1 more source

Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors [PDF]

open access: bronze, 1969
John J. Costanzi   +2 more
openalex   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy

open access: yesInternational Journal of Nanomedicine, 2018
Jicai Zhang, Xiang Xiao, Jianming Zhu, Ziyun Gao, Xianliang Lai, Xingen Zhu, Guohua Mao Department of Neurosurgery, Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China Purpose: Glioblastoma multiforme (GBM) is the most common ...
Zhang J   +6 more
doaj  

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl   +6 more
wiley   +1 more source

Review of abiotic and biotic elicitors’ roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn.) G. Don)

open access: yesJournal of Medicinal Plants, 2020
Background: Based on recent statistical survey, the cancer is the third important factor in Iran mortality. Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment ...
Saleh Amiri   +4 more
doaj  

Acute coronary syndrome developed after vincristine administration

open access: bronze, 2011
Serkan Öztürk   +4 more
openalex   +2 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene‐Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Bofu Deng   +9 more
wiley   +1 more source

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