Results 21 to 30 of about 3,914,198 (256)
Vinyl sulfones: selective and tunable covalent warheads against challenging enzyme targets [PDF]
Exploration of Drug ScienceOver the past several decades there has been a growing recognition of the role that covalent drug candidates have played in the drug development process. With this recognition, compounds that are capable of selectively and irreversibly inactivating their
Ronald E. Viola
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Vinyl Polymerizationby Organocalcium Compound.
The Journal of the Society of Chemical Industry, Japan, 1959 カルシウムテトラエチル亜鉛CaZn(C2H5)4が,スチレン,メタクリル酸メチルおよびアクリロニトリルなどのビニル化合物に対して有効な重合触媒となることがわかった。カルシウムテトラエチル亜鉛は,Gilmanの方法によって,ジェチル亜鉛とカルシウム金属とから合成した。酢酸ビニル,塩化ビニル,アクリル酸メチルなどはこの触媒では重合しなかった。酸素,キノン類などはこの重合を抑制した。メタクリル酸メチルとスチレンとの共重合では,典型的な「陰イオン的」単量体反応性比が見出された。動力学的研究の結果,見かけの活性化エネルギーの値はかなり小であり,また1分子停止機構が妥当と考えられる。これらの事実の重合反応が陰イオン機構によっていることを支持する。この触媒によって得られたポリスチレンについて,赤外吸収スペクトル ...
Junji Furukawa +3 more
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Rich methane laminar flames doped with light unsaturated hydrocarbons. Part II: 1,3butadiene [PDF]
, 2007 In line with the study presented in the part I of this paper, the structure of a laminar rich premixed methane flame doped with 1,3-butadiene has been investigated.
Allara +47 more
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Phosphoranaloga von Aminosäuren und Peptiden: Kettenverlängerung von Carbonylverbindungen
CHIMIA, 1982 Synthesis of carbonyl compounds 5 involving the Wittig-Horner reaction of diethyl-1-isocyanoalkylphosphonate 1 with carbonyl compounds 2 and subsequent hydrolysis of the vinyl isocyanides 3 formed is reported.
Janusz Rachoń
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ACS Medicinal Chemistry Letters, 2019 The main pathway responsible for cellular regulation against oxidative stress is nuclear factor E2-related factor-2 (Nrf2) signaling. We previously synthesized and reported a novel vinyl sulfone (1) as an Nrf2 activator with therapeutic potential for ...
J. Choi +8 more
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Bacteriochlorophylls modified at position C-3 [PDF]
, 1992 [3-Vinyl]-bacteriochlorophyll a and related pigments modified at C-3 and/or C-132 have been synthesized from bacteriochlorophyll a. The reactivity at C-3 is strongly influenced by the C-132 substituent, and vice versa. Spectroscopical data and comparison
Cmiel, Edmund +4 more
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Oxycyanation of Vinyl Compounds
The Journal of the Society of Chemical Industry, Japan, 1971 イソプチレン, スチレン, 塩化ビニル, アクリロニトリルならびにベンゼンのナキシシアン化反応を行なった。イソブチレンからはβ,β-ジメチルアクリロニトリルが生成した。イソブチレンのオキシシアン化反応の動力学的挙動はエチレンに似ている。スチレンからは cis-β-ならびに trans-β-フェニルアクリロニトリルが生成した。塩化ビニルからはα-, cis-β- ならびに trans-β-クロロアクリロニトリルが得られた。β-クロロアクリロニトリルより逐次的にフマロニトリルが生成した。アクリロニトリルのオキシシアン化によりフマロニトリルが得られたが, その量は塩化ビニルのオキシシアン化により得られたフマロニトリルよりぎわめて少なかった。ベンゼンよりベンゾニトリルが得られた ...
Naoya KOMINAMI +3 more
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Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center [PDF]
, 2018 Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields.
Gonzalo Calvo, Gonzalo de
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Synthesis and Evaluation of Thiochroman-4-One Derivatives as Potential Leishmanicidal Agents
Molecules, 2017 The S-containing heterocyclic compounds benzothiopyrans or thiochromones stand out as having promising biological activities due to their structural relationship with chromones (benzopyrans), which are widely known as privileged scaffolds in medicinal ...
Esteban Vargas +4 more
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Beilstein Journal of Organic Chemistry, 2021 The reported flow-batch approach enables the easy preparation of 2H-azirines and their stereoselective transformation into highly functionalized NH-aziridines, starting from vinyl azides and organolithium compounds.
Michael Andresini +2 more
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