Results 111 to 120 of about 2,464,659 (364)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Intimate Partner Violence and Sexual Violence in the Aleutian/Pribilof Island Region: Key Results from the 2014 and 2015 Alaska Victimization Surveys [PDF]

, 2018
This document is a two-page summary of the key results from the 2014–2015 Alaska Victimization Survey (AVS) for the Aleutian/Pribilof Island region, which was conducted from April to June 2014 and May to August 2015, with results released on March 13 ...
Rosay, André B.
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Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Descriptive Analysis of Domestic Violence and Sexual Assault Incidents Closed by the Alaska State Troopers: 2008–2011 — Final Report [PDF]

, 2015
This report presents a descriptive analysis of sexual assault and domestic violence incidents closed by the Alaska State Troopers for the period January 1, 2008 through December 31, 2011, as part of an effort to systematically document the formal ...
Myrstol, Brad A., Parker, Khristy L.
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Stepping together for children after trauma: protocol for a randomized controlled trial of a parent-led treatment in first-line services (NorStep Study)

European Journal of Psychotraumatology
Background: Childhood trauma is a public health challenge, and there is currently a service/needs gap. Low-intensive treatments where the task of leading the treatment is partially shifted to a caregiver can help bridge this gap by freeing therapist ...
Silje Mørup Ormhaug, Tine K. Jensen, Kate Louise Porcheret, Anne Lie Andreassen, Sarah Byford, Else Merete Kvalsvik Fagermoen, Pernille Gurandsrud, Kristin Johanne Økern Haabrekke, Marie Lindebø Knutsen, Heidi Maria Päivärinne, Ingeborg Skjærvø   +10 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Fifty Shades of Blue and Grey: Civil War Torture Porn? [PDF]

, 2012
Over the past few days I\u27ve been thinking about violence. We are a culture of violence. We idolize blind rage and violence, we normalize it and worship it....
Rudy, John M.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Young Guns: How Gun Violence Is Devastating the Millennial Generation [PDF]

, 2014
While guns play a role in so many deaths of America's youth, very few public health research dollars are spent to understand the causes of this epidemic and develop policy solutions to address it.
Anne Johnson, Chelsea Parsons
core