Results 131 to 140 of about 2,799,905 (389)

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Consensual Violence: A Cultural Contradiction

open access: yes, 2015
In American culture, violence is typically understood as inherently negative; no one would want to be personally subjected to violence because violence by its very nature is undesirable. Thus, the idea of seeking out violence seems paradoxical.
Rivoli, Lisa R.
core  

Intimate Partner Violence and Sexual Violence in the Aleutian/Pribilof Island Region: Key Results from the 2014 and 2015 Alaska Victimization Surveys [PDF]

open access: yes, 2018
This document is a two-page summary of the key results from the 2014–2015 Alaska Victimization Survey (AVS) for the Aleutian/Pribilof Island region, which was conducted from April to June 2014 and May to August 2015, with results released on March 13 ...
Rosay, André B.
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Intimate Partner Violence and Sexual Violence in the Municipality of Anchorage: Key Results from the 2011 Alaska Victimization Survey [PDF]

open access: yes, 2011
This document is a two-page summary of the key results from the 2011 Alaska Victimization Survey for the Municipality of Anchorage, which was conducted from April to June 2011, with results released on October 3, 2011 in Anchorage. Findings include: *
Rosay, André B.
core  

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