Results 31 to 40 of about 243,714 (266)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Testing the leadership and organizational change for implementation (LOCI) intervention in Norwegian mental health clinics: a stepped-wedge cluster randomized design study protocol

Implementation Science, 2019
Background Alignment across levels of leadership within an organization is needed for successful implementation of evidence-based practice. The leadership and organizational change for implementation (LOCI) intervention is a multi-faceted multilevel ...
Karina M. Egeland, Ane-Marthe Solheim Skar, Mathilde Endsjø, Erlend Høen Laukvik, Harald Bækkelund, Aida Babaii, Lene Beate Granly, Gry Kristina Husebø, Randi Hovden Borge, Mark G. Ehrhart, Marisa Sklar, C. Hendricks Brown, Gregory A. Aarons   +12 more
doaj   +1 more source

Healthcare utilization after mass trauma: a register-based study of consultations with primary care and mental health services in survivors of terrorism

BMC Psychiatry, 2022
Background Knowledge on healthcare utilization after mass trauma is needed to strengthen the public health preparedness to such incidents. Using register-based data, this study had a unique opportunity to investigate how young survivors’ use of primary ...
Lise Eilin Stene, Siri Thoresen, Tore Wentzel-Larsen, Grete Dyb   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

‘My child could have died’: counterfactual thoughts and psychological distress in parents of trauma survivors

European Journal of Psychotraumatology
Background: After exposure to a potentially traumatic event, survivors may experience thoughts about ‘what could have happened’, referred to as counterfactual thoughts (CFTs).
Ines Blix, Kristin Alve Glad, Andrea Undset, Tore Wentzel-Larsen, Akiah Astral Ottesen, Tine K. Jensen, Grete Dyb   +6 more
doaj   +1 more source

Does posttraumatic stress predict frequency of general practitioner visits in parents of terrorism survivors? A longitudinal study

European Journal of Psychotraumatology, 2017
Background: Life threat to children may induce severe posttraumatic stress reactions (PTSR) in parents. Troubled mothers and fathers may turn to their general practitioner (GP) for help.
Jon Magnus Haga, Lise Eilin Stene, Siri Thoresen, Tore Wentzel-Larsen, Grete Dyb   +4 more
doaj   +1 more source

The relationship between posttraumatic stress symptoms and narrative structure among adolescent terrorist-attack survivors

European Journal of Psychotraumatology, 2016
Background: The structure of trauma narratives is considered to be related to posttraumatic stress symptomatology and thus the capacity to make a coherent narrative after stressful events is crucial for mental health.
Petra Filkuková, Tine K. Jensen, Gertrud Sofie Hafstad, Hanne Torvund Minde, Grete Dyb   +4 more
doaj   +1 more source

Measuring implementation climate: psychometric properties of the Implementation Climate Scale (ICS) in Norwegian mental health care services

BMC Health Services Research, 2022
Background Employees’ perceptions of organizational climate for implementation of new methods are important in assessing and planning for implementation efforts.
Nadina Peters, Randi Hovden Borge, Ane- Marthe Solheim Skar, Karina M. Egeland   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Is perceived safety and threat after workplace terrorism linked to employee sick-leave? A registry-based longitudinal study of governmental employees in Norway

European Journal of Psychotraumatology, 2020
Background A large body of research has shown that terrorism enhances fears and undermines perceived safety in a high proportion of both directly exposed individuals and individuals without any form of direct exposure (i.e.
Alexander Nissen, Mona Berthelsen, Maria Teresa Grønning Dale, Marianne Bang Hansen, Trond Heir   +4 more
doaj   +1 more source