Results 41 to 50 of about 243,714 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Trends in views of democracy and society and support for political violence in the USA, 2022–2024: findings from a nationally representative survey

Injury Epidemiology
Background In 2022, a nationally representative longitudinal survey in the USA found concerningly high prevalences of support for and personal willingness to engage in political violence, but those prevalences decreased in 2023.
Garen J. Wintemute, Andrew Crawford, Elizabeth A. Tomsich, Veronica A. Pear   +3 more
doaj   +1 more source

Police Views of Suicidal Persons and the Law Criminalizing Attempted Suicide in Ghana: A Qualitative Study With Policy Implications

SAGE Open, 2017
The penal code of Ghana condemns suicide attempt. The present study sought to explore the views of the police on persons who attempt suicide and the law criminalizing the act.
Joseph Osafo, Charity S. Akotia, Emmanuel N.-B. Quarshie, Kofi E. Boakye, Johnny Andoh-Arthur   +4 more
doaj   +1 more source

Association of medical conditions and firearm suicide among legal handgun purchasers in California: a case–control study

Injury Epidemiology, 2023
Background Suicide is a pressing public health problem, and firearm owners are at especially elevated risk. Certain health conditions are markers of suicide risk, but more research is needed on clinical risk markers for suicide among firearm owners ...
Julia P. Schleimer, Rose M. C. Kagawa, Hannah S. Laqueur   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Changes in firearm intentions and behaviors after the 2024 United States presidential election

Injury Epidemiology
Background Firearm purchasing patterns, intentions, and behaviors change over time in response to specific events. Additionally, the nature of these changes may be evolving over time or differ depending on the nature of the event in question.
Michael D. Anestis, Allison E. Bond, Kimberly C. Burke, Sultan Altikriti, Daniel C. Semenza   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Political affiliation moderates the link between gun violence exposure and firearm behaviors via perceptions of utility, safety, and threat

Injury Epidemiology
Background Gun violence exposure (GVE) is associated with a range of cognitive and behavioral outcomes. However, few studies have assessed how different forms of GVE relate to perceptions of safety, threat sensitivity, and views about the utility of ...
Sultan Altikriti, Daniel C. Semenza, Michael D. Anestis   +2 more
doaj   +1 more source