Results 61 to 70 of about 2,254,091 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Health care needs, experiences, and satisfaction after terrorism: a longitudinal study of parents of survivors of the Utøya attack

BMC Health Services Research
Background There is scarce knowledge on the health care follow-up of parents of terror attack survivors. This study focused on the mothers and fathers of survivors and examined (1) their perceived health care needs relative to their psychological ...
Ida Frugård Strøm, Tore Wentzel-Larsen, Synne Stensland, Grete Dyb, Lise Eilin Stene   +4 more
doaj   +1 more source

The mediating role of shame in the relationship between childhood bullying victimization and adult psychosocial adjustment

European Journal of Psychotraumatology, 2018
Background: Psychological distress following experiencing bullying victimization in childhood has been well documented. Less is known about the impact of bullying victimization on psychosocial adjustment problems in young adulthood and about potential ...
Ida Frugård Strøm, Helene Flood Aakvaag, Marianne Skogbrott Birkeland, Erika Felix, Siri Thoresen   +4 more
doaj   +1 more source

Preventing Gun Violence in Pediatrics [PDF]

, 2018
Learn about the Violence Prevention Initiative at Children’s Hospital of Philadelphia, which has become a national and global model for hospital-based and communitydelivered violence prevention through educational programming in schools and the community,
Myers, PhD, Rachel
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A parallel investigation of trauma exposure, maladaptive appraisals and posttraumatic stress reactions in two groups of trauma-exposed adolescents

European Journal of Psychotraumatology
Background: Maladaptive appraisals, such as thoughts about experiencing a permanent and disturbing change and about being a fragile person in a scary world, are associated with posttraumatic stress reactions (PTSR) for trauma-exposed children and ...
Andrea Undset, Tine K. Jensen, Grete Dyb, Tore Wentzel-Larsen, Silje M. Ormhaug, Synne Stensland, Ines Blix   +6 more
doaj   +1 more source

Alaska Victimization Survey: 2011 Results for Bristol Bay [PDF]

, 2011
This is a handout of a Powerpoint slide presentation providing an overview of key results from the 2011 Alaska Victimization Survey for the Bristol Bay region, which was conducted from April to June 2011, with results released on October 12, 2011 in ...
Morton, Lauree, Myrstol, Brad A., Rivera, Marny, Rosay, André B., Wood, Darryl S.   +4 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Qollateral: The Impact of QAnon on Loved Ones and the Potential for P/CVE Programs to Help

Journal for Deradicalization, 2023
Since 2017, the conspiracy theory known as QAnon has boomed in popularity and spread across national borders. While QAnon is linked to various violent criminal acts, including the January 6th riots on Capitol Hill in Washington, D.C., there is abundant ...
Michèle St-Amant , Michael King , Laura Stolte , Marc-André Argentino   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source