Results 71 to 80 of about 91,050 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fear, loathing, and support for political violence in the United States: findings from a nationally representative surveyResearch in context

The Lancet Regional Health. Americas
Summary: Background: Racism, hostile sexism, homonegativity, transphobia, xenophobia, antisemitism, and Islamophobia increase risk for perpetration of interpersonal violence generally.
Garen J. Wintemute, Bradley Velasquez, Aaron B. Shev, Elizabeth A. Tomsich, Mona A. Wright, Paul M. Reeping, Sonia L. Robinson, Daniel J. Tancredi, Veronica A. Pear   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A theory of change for community interventions to prevent domestic violence against women and girls in Mumbai, India [version 2; peer review: 2 approved]

Wellcome Open Research, 2019
Background: We describe the development of a theory of change for community mobilisation activities to prevent violence against women and girls. These activities are part of a broader program in urban India that works toward primary, secondary, and ...
Nayreen Daruwalla, Surinder Jaswal, Prakash Fernandes, Preethi Pinto, Ketaki Hate, Gauri Ambavkar, Bhaskar Kakad, Lu Gram, David Osrin   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Rates of out-of-home care among children in Canada: an analysis of national administrative child welfare data

Health Promotion and Chronic Disease Prevention in Canada
IntroductionAs a part of the public health approach to child welfare, data about children placed in out-of-home care are needed to assess population trends, understand drivers of social and health inequities, and examine outcomes for
Nathaniel J. Pollock, Alexandra M. Ouédraogo, Nico Trocmé, Wendy Hovdestad, Amy Miskie, Lindsay Crompton, Aimée Campeau, Masako Tanaka, Cindy Zhang, Claudie Laprise, Lil Tonmyr   +10 more
doaj   +1 more source

Using the PhotoStory Method to understand the cultural context of youth victimisation in the Punjab [PDF]

International Journal of Emotional Education, 2015
Bullying is an international issue that is only just beginning to be researched in India and anecdotal evidence in Punjab, India, has suggested that most schools in the Punjab are in denial about bullying on campus.
Grace Skrzypiec, Phillip Slee, Damanjit Sandhu   +2 more
doaj  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The ethics of knowledge sharing: a feminist examination of intellectual property rights and open-source materials in gender transformative methodologies

Frontiers in Research Metrics and Analytics
Debates on intellectual property rights and open source frequently stem from the business sector and higher education, where goals are typically oriented toward profit, academic status, credit, and/or reputation.
Leah Goldmann, Alice Welbourn, Diane Gillespie, Nastnet Ghebrebhran, Lufuno Barro, Sara Siebert, Hawa Kagoya, Lori Michau, Anjalee Kohli, Tina Musuya, Sonia Rebecca Kusiima   +10 more
doaj   +1 more source