Results 61 to 70 of about 92,388 (260)
Advanced Science, EarlyView.To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao +8 more
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Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
Zhongguo cuzhong zazhi目的 探讨空腹血糖与接受静脉溶栓的缺血性卒中患者功能结局的关系。 方法 回顾性收集2018年10月—2020年11月首都医科大学附属北京天坛医院静脉溶栓患者的病历资料。纳入发病4.5 h内接受阿替普酶静脉溶栓的缺血性卒中患者为研究对象，采集相关研究数据（包括空腹血糖等）。研究结局设定为出院时功能结局良好，即mRS评分0～1分。采用多因素logistic回归分析探讨空腹血糖与功能结局的关联性。 结果 共入组205例患者，平均年龄为（63.21±11.67）岁，其中153例（74.63%）患者为男性 ...
丁则昱1，李光硕1，赵性泉1，2 (DING Zeyu1, LI Guangshuo1, ZHAO Xingquan1,2 )
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Advanced Science, EarlyView.Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen +14 more
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Factors affecting the length of fiber post and core structure: a literature review
口腔疾病防治, 2017 An ideal balance between the post length within root and the coronal extension should exist. Some theo⁃ ries advocated the use of the longest post as possible as the apical seal is not disturbed. Others advocated that the post should be longer than the
LIN Jie +4 more
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Advanced Science, EarlyView.Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin +13 more
wiley +1 more source
Zhongguo cuzhong zazhi2024年6月，《中华神经科杂志》发布了更新版的《中国急性缺血性卒中诊治指南2023》。该指南基于最新的循证医学证据，提供了急性缺血性卒中（acute ischemic stroke，AIS）诊治的最新推荐意见，涵盖急性期静脉溶栓、机械取栓、二级预防抗血小板治疗等多个方面。本文深入剖析这些关键推荐，结合AIS领域的最新研究成果，对相关文献进行深入解读。本文旨在清晰呈现AIS的最新诊治规范，为临床医师提供实用的指导，以更好地服务AIS患者，改善其治疗效果。 Abstract: In June ...
李光硕1，赵性泉1，2 (LI Guangshuo1, ZHAO Xingqua1,2 )
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In‐Memory Continuous‐Time SAT Solver Based on Bidirectional 11‐T SRAM Macro
Advanced Intelligent Systems, EarlyView.This article reported a continuous‐time (CT) Boolean satisfiability (SAT) problem solver using bidirectional 11T‐SRAM macro. The proposed system operates asynchronously using capacitor‐based gradient integration and maximizes the parallelism for SAT solving by in‐memory computing (IMC).
Dongseok Kwon +3 more
wiley +1 more source
AnimalsA 2-year-old neutered female domestic shorthair cat presented with chronic, progressively worsening upper respiratory symptoms that were unresponsive to long-term medical treatment.
Hyomi Jang +5 more
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Scientific Reports, 2019 In this study we developed a deep learning (DL) algorithm that detects errors in retinal never fibre layer (RNFL) segmentation on spectral-domain optical coherence tomography (SDOCT) B-scans using human grades as the reference standard.
Alessandro A. Jammal +6 more
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