Results 71 to 80 of about 92,807 (260)

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

open access: yesAdvanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku   +4 more
wiley   +1 more source

Evaluation of the Effect of Curriculum Ideology and Politics in Medical PsychologyTeaching for Undergraduate Students

open access: yesGuoji laonian yixue zazhi
Objective This study was conducted to observe the effect of curriculum ideology and politics in the teaching of medical psychology by integrating curriculum ideology and politics in the teaching of medical psychology in the five-year system of clinical ...
Chang Li   +4 more
doaj   +1 more source

Detecting Retinal Nerve Fibre Layer Segmentation Errors on Spectral Domain-Optical Coherence Tomography with a Deep Learning Algorithm

open access: yesScientific Reports, 2019
In this study we developed a deep learning (DL) algorithm that detects errors in retinal never fibre layer (RNFL) segmentation on spectral-domain optical coherence tomography (SDOCT) B-scans using human grades as the reference standard.
Alessandro A. Jammal   +6 more
doaj   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

open access: yesAdvanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen   +19 more
wiley   +1 more source

Frontal Sinus Trephination and Repeated Irrigation in a Cat with Chronic Rhinosinusitis: A Case Report

open access: yesAnimals
A 2-year-old neutered female domestic shorthair cat presented with chronic, progressively worsening upper respiratory symptoms that were unresponsive to long-term medical treatment.
Hyomi Jang   +5 more
doaj   +1 more source

Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

open access: yesInternational Journal of Genomics, 2019
Background. The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these ...
Lin Li, Xue Zhang, Zhong-Ti Zhang
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

open access: yesAdvanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang   +14 more
wiley   +1 more source

Refractory Multiple Myeloma in a West Highland White Terrier: Clinical Presentations and Therapeutic Interventions

open access: yesAnimals
This report presents the case of a seven-year-old West Highland White Terrier diagnosed with relapsed and refractory multiple myeloma (MM), managed using multiple treatment approaches, including conventional chemotherapy (melphalan, vincristine ...
Hyomi Jang   +8 more
doaj   +1 more source

A Normotensive Patient with Primary Aldosteronism

open access: yesCase Reports in Endocrinology, 2017
This study was to report a case of normotensive patient with primary aldosteronism who was admitted to our department recently. The patient was a 33-year-old male with right adrenal incidentaloma, but without any symptom.
Xiao Lin   +3 more
doaj   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

open access: yesAdvanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li   +23 more
wiley   +1 more source

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