Results 81 to 90 of about 1,959,636 (236)
Junín Virus Pathogenesis and Virus Replication
Viruses, 2012 Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina.
Olga Kolokoltsova +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Спортивная медицина: наука и практикаAim of the study: To study the quantitative dynamics of the myocardial damage marker troponin T (cTnT) in elite biathlonists as a response to the cyclic training aids used at the stages of the early season during the annual training cycle.Methods: The ...
M. A. Dikunets +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
İzmir ili kiraz üretim alanlarında görülen virüs hastalıklarının belirlenmesi üzerinde araştırmalar
, 2006 Bu çalışma ile zmir ili Kiraz üretim alanlarında görülen virüs hastalıkları ve yaygınlık oranları saptanmıştır. 2004 ve 2005 yıllarında yapılan arazi gözlemlerinde zmir ilininde kiraz üretimi yapan değişik yörelerden 400 örnek toplanmıştır.
Paylan, İsmail Can
core
Genel Tıp Dergisi, 2018 Amaç: Bu çalışmada, hemodiyaliz tedavisi uygulanan ve uygulanmayan inaktif hepatit B taşıyıcılarında Transfusion Transmitted Virus TTV prevalansının saptanması amaçlandı.Gereç ve Yöntem: Bu çalışma, hemodiyaliz tedavisi uygulanan 50 inaktif hepatit B ...
Onur Ural +5 more
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2005 Bu çalışmada Bursa ve Çanakkale illerinin önemli şeker pancarı üretim alanlarında görülen virüs hastalıkları ve yaygınlık oranları saptanmaya çalışılmıştır.
Tok, Serpil
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source