Results 121 to 130 of about 203,793 (303)

Identification and Molecular Characterization of the Chloroplast Targeting Domain of Turnip yellow mosaic virus Replication Proteins

Frontiers in Plant Science, 2017
Turnip yellow mosaic virus (TYMV) is a positive-strand RNA virus infecting plants. The TYMV 140K replication protein is a key organizer of viral replication complex (VRC) assembly, being responsible for recruitment of the viral polymerase and for ...
Lucille Moriceau, Lucille Moriceau, Lucile Jomat, Stéphane Bressanelli, Catherine Alcaide-Loridan, Isabelle Jupin   +5 more
doaj   +1 more source

Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]

, 2015
Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...

core   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection [PDF]

, 2011
Copyright © 2012, American Society for Microbiology. All Rights ReservedThe influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
B. Nal, Barman, Barman, Bruce, Carlton, Chen, Chen, Chen, Cheung, Ciampor, Compans, Creutz, Cubells, Eierhoff, Enrich, F. Kien, Formstecher, Fromont-Racine, Gannagé, Gerke, Goswami, Grantham, Guan, Gujuluva, H. Ma, Harris, Hartshorn, Henkel, Hoffmann, Holsinger, Honda, Hui, Ichinohe, Iwatsuki-Horimoto, K. S. Tse, L. L. M. Poon, Lakadamyali, Lamb, Lamb, Lee, Li, Liu, M. Maniere, McCown, McCown, Monastyrskaya, N. Lagarde, Nayak, Nefkens, Noton, Palese, Pinto, Pinto, Pinto, Pleschka, Rossman, Rossman, Rossman, Scheiffele, Simpson-Holley, Smythe, Sun, Thaa, Thomas, Ueda, Vila de Muga, Wang, Wang, Welsch, Y. Zhang   +69 more
core   +2 more sources

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Lysyl Oxidase-like Protein Recognizes Viral Envelope Proteins and Bacterial Polysaccharides against Pathogen Infection via Induction of Expression of Antimicrobial Peptides. [PDF]

Viruses, 2022
Lu PY, Niu GJ, Hong PP, Wang JX.
europepmc   +1 more source

The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions [PDF]

, 2003
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41.
Chan, David C., Koshiba, Takumi
core  

Selection of functional human antibodies from retroviral display libraries [PDF]

, 2004
Antibody library technology represents a powerful tool for the discovery and design of antibodies with high affinity and specificity for their targets.
Urban, Johannes H., Schneider, Richard M., Compte, Marta, Finger, Carsten, Cichutek, Klaus, Álvarez-Vallina, Luis, Buchholz, Christian   +6 more
core   +2 more sources

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection

Frontiers in Immunology, 2018
Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke, Karin Stiasny, Stephan W. Aberle, Stefan Malafa, Georgios Tsouchnikas, Julia Schwaiger, Michael Kundi, Franz X. Heinz, Judith H. Aberle   +8 more
doaj   +1 more source