Results 101 to 110 of about 238,327 (306)

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source

MosaicSolver : a tool for determining recombinants of viral genomes from pileup data [PDF]

, 2014
Viral recombination is a key evolutionary mechanism, aiding escape from host immunity, contributing to changes in tropism and possibly assisting transmission across species barriers.
Burroughs, Nigel, Fannon, Jessica, Moore, Jonathan D., Fannon, Jessica M., Ryabov, Eugene V., Wood, Graham R., Evans, David J., Burroughs, Nigel John, Wood, Graham   +8 more
core   +1 more source

The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine

Drug Delivery
Recombinant DNA vaccines offer significant potential for disease prevention and therapy, but their clinical success is often limited by poor immunogenicity, low cellular uptake, instability, and inefficient delivery without proper carriers.
Yaminn Thant, Parin Watcharavongtip, Patumporn Jermsutjarit, Pablo Piñeyro, Nattika Nimmano, Dachrit Nilubol, Angkana Tantituvanont   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Deep Sequencing of H7N9 Influenza A Viruses from 16 Infected Patients from 2013 to 2015 in Shanghai Reveals Genetic Diversity and Antigenic Drift

mSphere, 2018
Influenza A virus (IAV) infections are a major public health concern, including annual epidemics, epizootic outbreaks, and pandemics. A significant IAV epizootic outbreak was the H7N9 avian influenza A outbreak in China, which was first detected in 2013 ...
Yong-Li Xiao, Lili Ren, Xi Zhang, Li Qi, John C. Kash, Yan Xiao, Fan Wu, Jianwei Wang, Jeffery K. Taubenberger   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Origin and Evolution of Viruses as Molecular Organisms

, 2009
Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core  

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Hui Wang, Tamas Dalmay, Kazusato Ohshima, Walsh, John A., Linfeng Huang, Ohshima, Kazusato, Wang, Hui, Denise W. Pallett, Pallett, Denise W., Liang Wang, Li, Zhigang, Thien Ho, Zhigang Li, John A. Walsh, Huang, Linfeng, Ho, Thien, Wang, Liang, Dalmay, Tamas   +17 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Endogenous Viral Etiology of Prion Diseases

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core