Results 121 to 130 of about 479,569 (300)

Contemporary evolution of the viral-sensing TLR3 gene in an isolated vertebrate population [PDF]

, 2021
Charli S. Davies, Martin Taylor, Martijn Hammers, Terry Burke, Jan Komdeur, Hannah L. Dugdale, David Richardson   +6 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Phylogenomics of Ichneumonoidea (Hymenoptera) and implications for evolution of mode of parasitism and viral endogenization (data files and alignments)

, 2020
Barbara J. Sharanowski, Ryan D. Ridenbaugh, Patrick Piekarski, Gavin R. Broad, Gaelen R. Burke, Andrew Deans, Alan R. Lemmon, Emily Claire Moriarty Lemmon, Gloria J. Diehl, James B. Whitfield, Heather M. Hines   +10 more
openalex   +1 more source

A network perspective on the virus world

Communicative & Integrative Biology, 2017
Viral evolution is characterized by high rates of horizontal gene transfer and fast sequence divergence. Furthermore, there are no universal genes shared by all viruses. As a result, distant relationships among viruses are better represented by a network
Jaime Iranzo, Mart Krupovic, Eugene V. Koonin   +2 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Detection and Phylogenetic Analysis of an Exotic Strain of Porcine Epidemic Diarrhea Virus and Its Effect on an Affected Herd Immunized Against the Endemic Strain in Thailand

Animals
Porcine epidemic diarrhea (PED) is caused by the PED virus, with genogroup 2 (G2), comprising G2a and G2b, being the primary contributors to outbreaks worldwide.
Christopher James Stott, Patumporn Jermsutjarit, Pornchai Pornpanom, Hongyao Lin, Angkana Tantituvanont, Dachrit Nilubol   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Evolutionary genomics of mycovirus-related dsRNA viruses reveals cross-family horizontal gene transfer and evolution of diverse viral lineages [PDF]

, 2012
Huiquan Liu, Yànpíng Fù, Jiǎtāo Xiè, Jiāsēn Chéng, Said A. Ghabrial, Guoqing Li, You‐Liang Peng, Xianhong Yi, Dàohóng Jiāng   +8 more
openalex   +1 more source

Epidemiological characteristics and precise prophylaxis and control of primary liver cancer in China

Guangxi Yike Daxue xuebao
In China, the prevalence of primary liver cancer (PLC) is higher in the South than in the North, higher in the littoral than in the interior, and higher in the rural areas than in the urban areas. Male-to-female ratio of PLC is 3: 1. In the past 20 years,
CAO Guangwen
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source