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Designing a multi-epitope vaccine against African swine fever virus using immunoinformatics approach
Scientific ReportsAfrican swine fever (ASF) is a highly contagious and fatal haemorrhagic disease affecting domestic and wild pigs, with no effective vaccine currently available.
Dhithya Venkateswaran +6 more
doaj +1 more source
mBio, 2019 In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, and convalescent illness in 83 participants ...
Kathie-Anne Walters +18 more
doaj +1 more source
, 2013 Viruses are ideal objects for studying evolutionary processes because of their short generation time, high numbers of offspring that they produce during infection and not least because of their simple structure. Viruses must continuously adapt to the conditions of their host or their host populations, so selection mechanisms are accessible to ...
Modrow, Susanne +3 more
openaire +1 more source
The Evolution of Endogenous Viral Elements [PDF]
Cell Host & Microbe, 2011 Endogenous retroviruses are a common component of the eukaryotic genome, and their evolution and potential function have attracted considerable interest. More surprising was the recent discovery that eukaryotic genomes contain sequences from RNA viruses that have no DNA stage in their life cycle. Similarly, several single-stranded DNA viruses have left
openaire +2 more sources
Learning the language of viral evolution and escape [PDF]
Science, 2020 Natural language predicts viral escape Viral mutations that evade neutralizing antibodies, an occurrence known as viral escape, can occur and may impede the development of vaccines. To predict which mutations may lead to viral escape, Hie et al.
Hie, Brian +3 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Open questions in enterovirus uncoating
Journal of VirologyEnterovirus uncoating, the events leading to the release of the viral genome into the cytoplasm, remains a poorly understood process. This review discusses two competing models: the “genome translocation model,” where viral proteins form a pore for RNA ...
Walker Symonds-Orr, Patrick T. Dolan
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology
, 2010 Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E +23 more
core +1 more source
Evolution of an Eurasian avian-like influenza virus in naïve and vaccinated pigs [PDF]
, 2012 The latest human influenza pandemic highlights the ability of influenza viruses to jump species barriers and emerge in new hosts, as well as the role of pigs in generating viruses with pandemic potential.
Pablo R Murcia +67 more
core +1 more source