Results 31 to 40 of about 220,643 (261)
Stochastic Modeling and Simulation of Viral Evolution [PDF]
Bulletin of Mathematical Biology, 2018 34 pages, 10 figures, 4 tables, 1 ...
Luiza Guimarães Fabreti +4 more
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npj Vaccines, 2021 Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. Stability assays were used to determine optimal
Luca T. Giurgea +9 more
doaj +1 more source
Viral evolution and Immune responses [PDF]
Journal of Clinical Microbiology and Biochemical Technology, 2019 Antiviral responses are activated rapidly after viral infection in order to control and prevent dissemination of the virus. Different pathways are activated in the immune system, including innate and adaptive responses. On the other hand, viruses have evolved specifi c strategies to evade these responses.
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Viral evolution and transmission effectiveness
World Journal of Virology, 2012 Different viruses transmit among hosts with different degrees of efficiency. A basic reproductive number (R0) indicates an average number of cases getting infected from a single infected case. R0 can vary widely from a little over 1 to more than 10. Low R0 is usually found among rapidly evolving viruses that are often under a strong positive selection ...
Patsarin, Rodpothong +1 more
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Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells
Frontiers in Immunology, 2023 After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan +6 more
doaj +1 more source
An adjusted ELISpot-based immunoassay for evaluation of SARS-CoV-2-specific T-cell responses
Biosafety and Health, 2022 Like antibody evaluation, using an effective antigen-specific T-cell immunity assessment method in coronavirus disease 2019 (COVID-19) patients, survivors and vaccinees is crucial for understanding the immune persistence, prognosis assessment, and ...
Hao Lin +7 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Genotype-by-inhibitor interactions to dissect enterovirus replication
Nature CommunicationsReplication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of mutations across viral proteins, it cannot resolve ...
William Bakhache +2 more
doaj +1 more source
The Evolution of Endogenous Viral Elements [PDF]
Cell Host & Microbe, 2011 Endogenous retroviruses are a common component of the eukaryotic genome, and their evolution and potential function have attracted considerable interest. More surprising was the recent discovery that eukaryotic genomes contain sequences from RNA viruses that have no DNA stage in their life cycle. Similarly, several single-stranded DNA viruses have left
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens +4 more
wiley +1 more source