Results 21 to 30 of about 220,643 (261)
The evolution of viral emergence [PDF]
Proceedings of the National Academy of Sciences, 2006 The current uncertainty over whether H5N1 avian influenza virus will successfully adapt to human transmission highlights the importance of understanding the evolutionary basis of viral emergence, particularly the respective roles played by ecology and genetics in allowing viruses to establish productive transmission networks in new host species.
openaire +2 more sources
Viral diseases and human evolution [PDF]
Memórias do Instituto Oswaldo Cruz, 2000 The interaction of man with viral agents was possibly a key factor shaping human evolution, culture and civilization from its outset. Evidence of the effect of disease, since the early stages of human speciation, through pre-historical times to the present suggest that the types of viruses associated with man changed in time.
Élcio de Souza Leal +1 more
openaire +4 more sources
iScience, 2022 Summary: The difficulty to unambiguously identify the various subsets of mononuclear phagocytes (MNPs) of the intestinal lamina propria has hindered our understanding of the initial events occurring after mucosal exposure to HIV-1.Here, we compared the ...
Mariangela Cavarelli +10 more
doaj +1 more source
mBio, 2018 Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine ...
Jae-Keun Park +9 more
doaj +1 more source
Nature Communications, 2022 There are competing hypotheses for human herpes simplex virus 2’s migration out-of-Africa. Here, the authors sequence 65 new herpes simplex virus 2 genomes with a focus on under-sampled sub-Saharan African countries, suggesting an Eastern African origin ...
Jennifer L. Havens +5 more
doaj +1 more source
Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS [PDF]
Current HIV/AIDS Reports, 2015 Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body, and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples collected either at autopsy ...
Maria M, Bednar +6 more
openaire +2 more sources
mBio, 2014 Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor.
Li Qi +11 more
doaj +1 more source
Inhibition of Superinfection and the Evolution of Viral Latency [PDF]
Journal of Virology, 2010 ABSTRACT Latent viruses generally defend their host cell against superinfection by nonlatent virulent mutants that could destroy the host cell. Superinfection inhibition thus seems to be a prerequisite for the maintenance of viral latency.
Berngruber, T. W. +2 more
openaire +2 more sources
mBio, 2016 Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate ...
Matthew J. Memoli +11 more
doaj +1 more source
Physics of Life Reviews, 2006 In the last two decades, viruses have been used as model systems to study evolution in short periods of time. Due to their characteristics, virus adapt rapidly to changing conditions, thus allowing the quantification of several evolutionary features under controlled laboratory conditions.
Manrubia Cuevas, Susanna, Lázaro, Ester
openaire +2 more sources